{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fiege JK"],"funding":["National Institute of Allergy and Infectious Diseases","U.S. Department of Health and Human Services","NIAID NIH HHS","NHLBI NIH HHS","National Institutes of Health"],"pagination":["1815-1827.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8665115"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(12)"],"pubmed_abstract":["Laboratory mice comprise an expeditious model for preclinical vaccine testing; however, vaccine immunogenicity in these models often inadequately translates to humans. Reconstituting physiologic microbial experience to specific pathogen-free (SPF) mice induces durable immunological changes that better recapitulate human immunity. We examined whether mice with diverse microbial experience better model human responses post vaccination. We co-housed laboratory mice with pet-store mice, which have varied microbial exposures, and then assessed immune responses to influenza vaccines. Human transcriptional responses to influenza vaccination are better recapitulated in co-housed mice. Although SPF and co-housed mice were comparably susceptible to acute influenza infection, vaccine-induced humoral "],"journal":["Cell host & microbe"],"pubmed_title":["Mice with diverse microbial exposure histories as a model for preclinical vaccine testing."],"pmcid":["PMC8665115"],"funding_grant_id":["75N93019C00051","R01 AI132962","R01 AI116678","R01 AI150600","R01 AI143828","T32 HL007741","HHSN272201400005C"],"pubmed_authors":["Mickelson CK","Shepherd FK","Matchett WE","Meyerholz DK","Stolley JM","Nanda H","Hamilton SE","Block KE","Fiege JK","Langlois RA","Vezys V","Wijeyesinghe S","Pierson MJ","Shen SS","Masopust D"],"additional_accession":[]},"is_claimable":false,"name":"Mice with diverse microbial exposure histories as a model for preclinical vaccine testing.","description":"Laboratory mice comprise an expeditious model for preclinical vaccine testing; however, vaccine immunogenicity in these models often inadequately translates to humans. Reconstituting physiologic microbial experience to specific pathogen-free (SPF) mice induces durable immunological changes that better recapitulate human immunity. We examined whether mice with diverse microbial experience better model human responses post vaccination. We co-housed laboratory mice with pet-store mice, which have varied microbial exposures, and then assessed immune responses to influenza vaccines. Human transcriptional responses to influenza vaccination are better recapitulated in co-housed mice. Although SPF and co-housed mice were comparably susceptible to acute influenza infection, vaccine-induced humoral ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-09T22:38:40.96Z","creation":"2025-02-19T03:26:21.098Z"},"accession":"S-EPMC8665115","cross_references":{"pubmed":["34731647"],"doi":["10.1016/j.chom.2021.10.001"]}}