{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu Z"],"funding":["Eye and Ear Foundation of Pittsburgh","National Eye Institute","NEI NIH HHS","Research to Prevent Blindness","University of Pittsburgh","National Institutes of Health","Glaucoma Research Foundation"],"pagination":["108809"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8665145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["213"],"pubmed_abstract":["Intracranial pressure (ICP) has been proposed to play an important role in the sensitivity to intraocular pressure (IOP) and susceptibility to glaucoma. However, the in vivo effects of simultaneous, controlled, acute variations in ICP and IOP have not been directly measured. We quantified the deformations of the anterior lamina cribrosa (ALC) and scleral canal at Bruch's membrane opening (BMO) under acute elevation of IOP and/or ICP. Four eyes of three adult monkeys were imaged in vivo with OCT under four pressure conditions: IOP and ICP either at baseline or elevated. The BMO and ALC were reconstructed from manual delineations. From these, we determined canal area at the BMO (BMO area), BMO aspect ratio and planarity, and ALC median depth relative to the BMO plane. To better account for t"],"journal":["Experimental eye research"],"pubmed_title":["Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo."],"pmcid":["PMC8665145"],"funding_grant_id":["T32 EY017271","R01 EY023966","R01EY013178","P30EY008098","R01EY022928","T32-EY017271","R01 EY022928","R01EY031708","R01 EY013178","R01EY023966","P30 EY008098","R01 EY028662","R01EY025011","R01 EY025011","R01EY028662","R01 EY031708"],"pubmed_authors":["Schmitt SE","Zhu Z","Wang B","Wollstein G","Wallace J","Sigal IA","Smith MA","Waxman S","Tyler-Kabara E","Ishikawa H","Schuman JS"],"additional_accession":[]},"is_claimable":false,"name":"Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo.","description":"Intracranial pressure (ICP) has been proposed to play an important role in the sensitivity to intraocular pressure (IOP) and susceptibility to glaucoma. However, the in vivo effects of simultaneous, controlled, acute variations in ICP and IOP have not been directly measured. We quantified the deformations of the anterior lamina cribrosa (ALC) and scleral canal at Bruch's membrane opening (BMO) under acute elevation of IOP and/or ICP. Four eyes of three adult monkeys were imaged in vivo with OCT under four pressure conditions: IOP and ICP either at baseline or elevated. The BMO and ALC were reconstructed from manual delineations. From these, we determined canal area at the BMO (BMO area), BMO aspect ratio and planarity, and ALC median depth relative to the BMO plane. To better account for t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T09:44:13.241Z","creation":"2025-04-05T09:44:13.241Z"},"accession":"S-EPMC8665145","cross_references":{"pubmed":["34736887"],"doi":["10.1016/j.exer.2021.108809"]}}