{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bloomfield SJ"],"funding":["biotechnology and biological sciences research council","palmerston north medical research foundation","royal society te apārangi rutherford discovery fellowship","institute of veterinary and biological sciences","Biotechnology and Biological Sciences Research Council"],"pagination":["72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8665580"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Campylobacter is a genus of bacteria that has been isolated from the gastrointestinal tract of humans and animals, and the environments they inhabit around the world. Campylobacter adapt to new environments by changes in their gene content and expression, but little is known about how they adapt to long-term human colonization. In this study, the genomes of 31 isolates from a New Zealand patient and 22 isolates from a United Kingdom patient belonging to Campylobacter jejuni sequence type 45 (ST45) were compared with 209 ST45 genomes from other sources to identify the mechanisms by which Campylobacter adapts to long-term human colonization. In addition, the New Zealand patient had their microbiota investigated using 16S rRNA metabarcoding, and their level of inflammation "],"journal":["Gut pathogens"],"pubmed_title":["Genomic adaptations of Campylobacter jejuni to long-term human colonization."],"pmcid":["PMC8665580"],"funding_grant_id":["RDF-MAU1701","BB/R012504/1","BBS/E/F/000PR10348"],"pubmed_authors":["Biggs PJ","French NP","Hayman DTS","Benschop J","Marshall JC","Kelly DJ","Fayaz A","Thornley C","Mather AE","Bloomfield SJ","Midwinter AC","Carter PE"],"additional_accession":[]},"is_claimable":false,"name":"Genomic adaptations of Campylobacter jejuni to long-term human colonization.","description":"<h4>Background</h4>Campylobacter is a genus of bacteria that has been isolated from the gastrointestinal tract of humans and animals, and the environments they inhabit around the world. Campylobacter adapt to new environments by changes in their gene content and expression, but little is known about how they adapt to long-term human colonization. In this study, the genomes of 31 isolates from a New Zealand patient and 22 isolates from a United Kingdom patient belonging to Campylobacter jejuni sequence type 45 (ST45) were compared with 209 ST45 genomes from other sources to identify the mechanisms by which Campylobacter adapts to long-term human colonization. In addition, the New Zealand patient had their microbiota investigated using 16S rRNA metabarcoding, and their level of inflammation ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-31T09:49:49.056Z","creation":"2025-04-05T15:22:56.961Z"},"accession":"S-EPMC8665580","cross_references":{"pubmed":["34893079"],"doi":["10.1186/s13099-021-00469-7"]}}