biostudies-literatureUnknown38(12)Gatimel N<h4>Purpose</h4>Does semi-automated vitrification have lower inter-operator variability and better clinical outcomes than manual vitrification?<h4>Methods</h4>Retrospective analyses of 282 patients whose embryos had been cryopreserved, manually with Irvine®-CBS® (MV) or semi-automatically vitrified with the GAVI® method (AV) (from November 2017 to September 2020). Both techniques were performed during the same period by 5 operators. Inter-operator variability was statistically analyzed between operators who performed the vitrification and those who performed the warming process to compare the intact survival rate (% embryos with 100% intact blastomeres) and the positive survival rate (at least 50% intact blastomeres). Additionally, the complete vitrification time was assessed for the 2 tecJournal of assisted reproduction and genetics3213-3222https://www.ebi.ac.uk/biostudies/studies/S-EPMC8666398biostudies-literatureSemi-automated versus manual embryo vitrification: inter-operator variability, time-saving, and clinical outcomes.PMC8666398Moreau JLeandri RDBettiol CParinaud JGatimel NfalseSemi-automated versus manual embryo vitrification: inter-operator variability, time-saving, and clinical outcomes.<h4>Purpose</h4>Does semi-automated vitrification have lower inter-operator variability and better clinical outcomes than manual vitrification?<h4>Methods</h4>Retrospective analyses of 282 patients whose embryos had been cryopreserved, manually with Irvine®-CBS® (MV) or semi-automatically vitrified with the GAVI® method (AV) (from November 2017 to September 2020). Both techniques were performed during the same period by 5 operators. Inter-operator variability was statistically analyzed between operators who performed the vitrification and those who performed the warming process to compare the intact survival rate (% embryos with 100% intact blastomeres) and the positive survival rate (at least 50% intact blastomeres). Additionally, the complete vitrification time was assessed for the 2 tec2021-01-01T00:00:00Z2021 Dec2025-04-05T09:43:10.678Z2025-04-05T09:43:10.678ZS-EPMC86663983475523610.1007/s10815-021-02346-3