{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(22)"],"submitter":["Xiao Y"],"pubmed_abstract":["<h4>Background</h4>Disruption of the DNA damage repair (DDR) gene is related to cancer progression, treatment selection, and is subjected to radiation and targeted therapies with limited success. This paper conducted a comprehensive analysis to explore the distribution of DDR mutations in Chinese pan-cancer patients.<h4>Methods</h4>A total of 10,284 consecutive cases were analyzed in 24 cancer types [non-small cell lung cancer (NSCLC) 29.0%, liver 12.0%, colorectum 10.7%, etc.]. Tumor tissue samples were subjected to next generation sequencing (NGS) using a 381 gene panel incorporating 100 microsatellite loci. The association of deleterious somatic DDR mutation (del-sDDR<sup>mut</sup>) with tumor mutational burden (TMB), microsatellite instability (MSI), programmed cell death-ligand 1 (PD-"],"journal":["Annals of translational medicine"],"pagination":["1661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8667116"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive analysis of DNA damage repair deficiency in 10,284 pan-cancer study."],"pmcid":["PMC8667116"],"pubmed_authors":["Xie W","Zheng Y","Lei M","Zhu Z","Yang L","Wang C","Xiao Y","Huang M","Lu D","Lin Y","Zhao X","Li Z","Chen Y","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of DNA damage repair deficiency in 10,284 pan-cancer study.","description":"<h4>Background</h4>Disruption of the DNA damage repair (DDR) gene is related to cancer progression, treatment selection, and is subjected to radiation and targeted therapies with limited success. This paper conducted a comprehensive analysis to explore the distribution of DDR mutations in Chinese pan-cancer patients.<h4>Methods</h4>A total of 10,284 consecutive cases were analyzed in 24 cancer types [non-small cell lung cancer (NSCLC) 29.0%, liver 12.0%, colorectum 10.7%, etc.]. Tumor tissue samples were subjected to next generation sequencing (NGS) using a 381 gene panel incorporating 100 microsatellite loci. The association of deleterious somatic DDR mutation (del-sDDR<sup>mut</sup>) with tumor mutational burden (TMB), microsatellite instability (MSI), programmed cell death-ligand 1 (PD-","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-06-01T03:23:16.303Z","creation":"2025-06-01T03:23:16.303Z"},"accession":"S-EPMC8667116","cross_references":{"pubmed":["34988170"],"doi":["10.21037/atm-21-5449"]}}