biostudies-literatureUnknown9(22)Xiao Y<h4>Background</h4>Disruption of the DNA damage repair (DDR) gene is related to cancer progression, treatment selection, and is subjected to radiation and targeted therapies with limited success. This paper conducted a comprehensive analysis to explore the distribution of DDR mutations in Chinese pan-cancer patients.<h4>Methods</h4>A total of 10,284 consecutive cases were analyzed in 24 cancer types [non-small cell lung cancer (NSCLC) 29.0%, liver 12.0%, colorectum 10.7%, etc.]. Tumor tissue samples were subjected to next generation sequencing (NGS) using a 381 gene panel incorporating 100 microsatellite loci. The association of deleterious somatic DDR mutation (del-sDDR^mut) with tumor mutational burden (TMB), microsatellite instability (MSI), programmed cell death-ligand 1 (PD-Annals of translational medicine1661https://www.ebi.ac.uk/biostudies/studies/S-EPMC8667116biostudies-literatureComprehensive analysis of DNA damage repair deficiency in 10,284 pan-cancer study.PMC8667116Xie WZheng YLei MZhu ZYang LWang CXiao YHuang MLu DLin YZhao XLi ZChen YZhao JfalseComprehensive analysis of DNA damage repair deficiency in 10,284 pan-cancer study.<h4>Background</h4>Disruption of the DNA damage repair (DDR) gene is related to cancer progression, treatment selection, and is subjected to radiation and targeted therapies with limited success. This paper conducted a comprehensive analysis to explore the distribution of DDR mutations in Chinese pan-cancer patients.<h4>Methods</h4>A total of 10,284 consecutive cases were analyzed in 24 cancer types [non-small cell lung cancer (NSCLC) 29.0%, liver 12.0%, colorectum 10.7%, etc.]. Tumor tissue samples were subjected to next generation sequencing (NGS) using a 381 gene panel incorporating 100 microsatellite loci. The association of deleterious somatic DDR mutation (del-sDDR^mut) with tumor mutational burden (TMB), microsatellite instability (MSI), programmed cell death-ligand 1 (PD-2021-01-01T00:00:00Z2021 Nov2025-06-01T03:23:16.303Z2025-06-01T03:23:16.303ZS-EPMC86671163498817010.21037/atm-21-5449