{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bogdanow B"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["e0293421"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8669474"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Cytomegaloviruses (CMVs) are among the largest pathogenic viruses in mammals. To enable replication of their long double-stranded DNA genomes, CMVs induce profound changes in cell cycle regulation. A hallmark of CMV cell cycle control is the establishment of an unusual cell cycle arrest at the G<sub>1</sub>/S transition, which is characterized by the coexistence of cell cycle stimulatory and inhibitory activities. While CMVs interfere with cellular DNA synthesis and cell division, they activate S-phase-specific gene expression and nucleotide metabolism. This is facilitated by a set of CMV gene products that target master regulators of G<sub>1</sub>/S progression such as cyclin E and A kinases, Rb-E2F transcription factors, p53-p21 checkpoint proteins, the APC/C ubiquitin ligase, and the nu"],"journal":["mBio"],"pubmed_title":["Emerging Mechanisms of G<sub>1</sub>/S Cell Cycle Control by Human and Mouse Cytomegaloviruses."],"pmcid":["PMC8669474"],"funding_grant_id":["BO 5917/1-1"],"pubmed_authors":["Phan QV","Wiebusch L","Bogdanow B"],"additional_accession":[]},"is_claimable":false,"name":"Emerging Mechanisms of G<sub>1</sub>/S Cell Cycle Control by Human and Mouse Cytomegaloviruses.","description":"Cytomegaloviruses (CMVs) are among the largest pathogenic viruses in mammals. To enable replication of their long double-stranded DNA genomes, CMVs induce profound changes in cell cycle regulation. A hallmark of CMV cell cycle control is the establishment of an unusual cell cycle arrest at the G<sub>1</sub>/S transition, which is characterized by the coexistence of cell cycle stimulatory and inhibitory activities. While CMVs interfere with cellular DNA synthesis and cell division, they activate S-phase-specific gene expression and nucleotide metabolism. This is facilitated by a set of CMV gene products that target master regulators of G<sub>1</sub>/S progression such as cyclin E and A kinases, Rb-E2F transcription factors, p53-p21 checkpoint proteins, the APC/C ubiquitin ligase, and the nu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T11:22:49.236Z","creation":"2022-02-11T15:42:31.328Z"},"accession":"S-EPMC8669474","cross_references":{"pubmed":["34903047"],"doi":["10.1128/mBio.02934-21"]}}