{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Wilkinson HN"],"pubmed_abstract":["Endogenous metals are required for all life, orchestrating the action of diverse cellular processes that are crucial for tissue function. The dynamic wound healing response is underpinned by a plethora of such cellular behaviours, occurring in a time-dependent manner. However, the importance of endogenous metals for cutaneous repair remains largely unexplored. Here we combine ICP-MS with tissue-level RNA-sequencing to reveal profound changes in a number of metals, and corresponding metal-regulated genes, across temporal healing in mice. Wound calcium, magnesium, iron, copper and manganese are elevated at 7 days post-wounding, while magnesium, iron, aluminium, manganese and cobalt increase at 14 days post-wounding. At the level of transcription, wound-induced pathways are independently high"],"journal":["Frontiers in cell and developmental biology"],"pagination":["788596"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8669724"],"repository":["biostudies-literature"],"pubmed_title":["Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair."],"pmcid":["PMC8669724"],"pubmed_authors":["Hardman MJ","Wilkinson HN","Guinn BA"],"additional_accession":[]},"is_claimable":false,"name":"Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair.","description":"Endogenous metals are required for all life, orchestrating the action of diverse cellular processes that are crucial for tissue function. The dynamic wound healing response is underpinned by a plethora of such cellular behaviours, occurring in a time-dependent manner. However, the importance of endogenous metals for cutaneous repair remains largely unexplored. Here we combine ICP-MS with tissue-level RNA-sequencing to reveal profound changes in a number of metals, and corresponding metal-regulated genes, across temporal healing in mice. Wound calcium, magnesium, iron, copper and manganese are elevated at 7 days post-wounding, while magnesium, iron, aluminium, manganese and cobalt increase at 14 days post-wounding. At the level of transcription, wound-induced pathways are independently high","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-08T09:59:01.105Z","creation":"2022-02-11T14:22:44.804Z"},"accession":"S-EPMC8669724","cross_references":{"pubmed":["34917621"],"doi":["10.3389/fcell.2021.788596"]}}