{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou CM"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["375-384"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8669835"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(2)"],"pubmed_abstract":["Pseudomonas aeruginosa is a severe Gram-negative opportunistic bacterium that causes a spectrum of organ system diseases, particularly in immunocompromised patients. This bacterium has been shown to induce unfolded protein response (UPR) during mammalian infection. Annexin A2 (AnxA2) is a multicompartmental protein relating to a number of cellular processes; however, it remains unknown whether AnxA2 coordinates a UPR pathway under bacterial infection conditions. Here, we report that the endoplasmic reticulum stress inositol-requiring enzyme 1 (IRE1)-X-box binding protein 1 (XBP1) pathway was up-regulated by AnxA2 through p38 MAPK signaling following P. aeruginosa infection in macrophages, whereas ATF4 and ATF6 not. In addition, XBP1 was found as a positive regulator of innate immunity to t"],"journal":["Journal of leukocyte biology"],"pubmed_title":["Annexin A2 regulates unfolded protein response via IRE1-XBP1 axis in macrophages during P. aeruginosa infection."],"pmcid":["PMC8669835"],"funding_grant_id":["R01 AI109317","P20 GM103442","R01 AI138203","P20 GM113123"],"pubmed_authors":["Pu Q","Lin P","Wu M","Wang B","Wu Q","Zhou CM","Yu XJ","Luo LM","Qin S"],"additional_accession":[]},"is_claimable":false,"name":"Annexin A2 regulates unfolded protein response via IRE1-XBP1 axis in macrophages during P. aeruginosa infection.","description":"Pseudomonas aeruginosa is a severe Gram-negative opportunistic bacterium that causes a spectrum of organ system diseases, particularly in immunocompromised patients. This bacterium has been shown to induce unfolded protein response (UPR) during mammalian infection. Annexin A2 (AnxA2) is a multicompartmental protein relating to a number of cellular processes; however, it remains unknown whether AnxA2 coordinates a UPR pathway under bacterial infection conditions. Here, we report that the endoplasmic reticulum stress inositol-requiring enzyme 1 (IRE1)-X-box binding protein 1 (XBP1) pathway was up-regulated by AnxA2 through p38 MAPK signaling following P. aeruginosa infection in macrophages, whereas ATF4 and ATF6 not. In addition, XBP1 was found as a positive regulator of innate immunity to t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T19:40:23.747Z","creation":"2025-04-04T19:40:23.747Z"},"accession":"S-EPMC8669835","cross_references":{"pubmed":["33225536"],"doi":["10.1002/jlb.3a1219-686rr","10.1002/JLB.3A1219-686RR"]}}