{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ouellette SP"],"funding":["NIAID NIH HHS","NCI NIH HHS","National Science Foundation (NSF)","NIGMS NIH HHS","National Science Foundation"],"pagination":["e0126921"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8670374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(6)"],"pubmed_abstract":["Chlamydia trachomatis and Streptococcus pyogenes are among the most prevalent bacterial pathogens of humans. Interestingly, both pathogens are tryptophan (Trp) auxotrophs and must acquire this essential amino acid from their environment. For Chlamydia, an obligate intracellular bacterium, this means scavenging Trp from the host cell in which they reside. For Streptococcus, a primarily extracellular bacterium, this means scavenging Trp from the local environment. In the course of a natural immune response, both pathogens can be exposed to Trp-limiting conditions through the action of the interferon gamma-inducible IDO1 enzyme, which catabolizes Trp to <i>N</i>-formylkynurenine. How these pathogens respond to Trp starvation is incompletely understood. However, we have previously demonstrated"],"journal":["mSystems"],"pubmed_title":["Codon-Dependent Transcriptional Changes in Response to Tryptophan Limitation in the Tryptophan Auxotrophic Pathogens Chlamydia trachomatis and Streptococcus pyogenes."],"pmcid":["PMC8670374"],"funding_grant_id":["P30 CA036727","P20 GM103427","1810599","F31 AI164863"],"pubmed_authors":["Hatch ND","Chaussee MS","Wood NA","Herrera AL","Ouellette SP"],"additional_accession":[]},"is_claimable":false,"name":"Codon-Dependent Transcriptional Changes in Response to Tryptophan Limitation in the Tryptophan Auxotrophic Pathogens Chlamydia trachomatis and Streptococcus pyogenes.","description":"Chlamydia trachomatis and Streptococcus pyogenes are among the most prevalent bacterial pathogens of humans. Interestingly, both pathogens are tryptophan (Trp) auxotrophs and must acquire this essential amino acid from their environment. For Chlamydia, an obligate intracellular bacterium, this means scavenging Trp from the host cell in which they reside. For Streptococcus, a primarily extracellular bacterium, this means scavenging Trp from the local environment. In the course of a natural immune response, both pathogens can be exposed to Trp-limiting conditions through the action of the interferon gamma-inducible IDO1 enzyme, which catabolizes Trp to <i>N</i>-formylkynurenine. How these pathogens respond to Trp starvation is incompletely understood. However, we have previously demonstrated","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-06-07T03:19:12.704Z","creation":"2025-02-19T02:57:47.179Z"},"accession":"S-EPMC8670374","cross_references":{"pubmed":["34904862"],"doi":["10.1128/mSystems.01269-21"]}}