biostudies-literatureCohen CCNational Center for Advancing Translational SciencesNutrition Science InitiativeNCATS NIH HHSNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNIH Office of the DirectorNINR NIH HHSe150996https://www.ebi.ac.uk/biostudies/studies/S-EPMC8670836biostudies-literatureUnknown131(24)BACKGROUNDHepatic de novo lipogenesis (DNL) is elevated in nonalcoholic fatty liver disease (NAFLD). Improvements in hepatic fat by dietary sugar reduction may be mediated by reduced DNL, but data are limited, especially in children. We examined the effects of 8 weeks of dietary sugar restriction on hepatic DNL in adolescents with NAFLD and correlations between DNL and other metabolic outcomes.METHODSAdolescent boys with NAFLD (n = 29) participated in an 8-week, randomized controlled trial comparing a diet low in free sugars versus their usual diet. Hepatic DNL was measured as percentage contribution to plasma triglyceride palmitate using a 7-day metabolic labeling protocol with heavy water. Hepatic fat was measured by magnetic resonance imaging-proton density fat fraction.RESULTSHepatic DThe Journal of clinical investigationDietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease.PMC8670836R01 NR019083n/aT32-DK07658UL1TR001442UL1 TR002378UL1 TR001442UL1TR002378R01 DK125701T32 DK007658Newton KPCarrier CACohen CCBeysen CVos MBNyangau EMWelsh JALi KWAlazraki ALUgalde-Nicalo PACleeton RLSchwimmer JBKnight-Scott JFigueroa JKnott CJDandan MSirlin CBHellerstein MKfalseDietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease.BACKGROUNDHepatic de novo lipogenesis (DNL) is elevated in nonalcoholic fatty liver disease (NAFLD). Improvements in hepatic fat by dietary sugar reduction may be mediated by reduced DNL, but data are limited, especially in children. We examined the effects of 8 weeks of dietary sugar restriction on hepatic DNL in adolescents with NAFLD and correlations between DNL and other metabolic outcomes.METHODSAdolescent boys with NAFLD (n = 29) participated in an 8-week, randomized controlled trial comparing a diet low in free sugars versus their usual diet. Hepatic DNL was measured as percentage contribution to plasma triglyceride palmitate using a 7-day metabolic labeling protocol with heavy water. Hepatic fat was measured by magnetic resonance imaging-proton density fat fraction.RESULTSHepatic D2021-01-01T00:00:00Z2021 Dec2026-05-31T01:03:45.557Z2025-04-04T11:31:34.292ZS-EPMC86708363490790710.1172/JCI15099610.1172/jci150996