biostudies-literatureKent DMNCATS NIH HHS2277-2286https://www.ebi.ac.uk/biostudies/studies/S-EPMC8672231biostudies-literatureUnknown326(22)<h4>Importance</h4>Patent foramen ovale (PFO)-associated strokes comprise approximately 10% of ischemic strokes in adults aged 18 to 60 years. While device closure decreases stroke recurrence risk overall, the best treatment for any individual is often unclear.<h4>Objective</h4>To evaluate heterogeneity of treatment effect of PFO closure on stroke recurrence based on previously developed scoring systems.<h4>Design, setting, and participants</h4>Investigators for the Systematic, Collaborative, PFO Closure Evaluation (SCOPE) Consortium pooled individual patient data from all 6 randomized clinical trials that compared PFO closure plus medical therapy vs medical therapy alone in patients with PFO-associated stroke, and included a total of 3740 participants. The trials were conducted worldwide JAMAHeterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.PMC8672231UL1 TR002544Song JKNelson JLee PHSoendergaard LDerumeaux GChatellier GFurlan AJLefebvre BCarroll JDSmalling RWKoethe BKim JSThaler DESaver JLMeier BReisman MHerrmann HCMas JLKasner SEMattle HPKent DMJuni PfalseHeterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.<h4>Importance</h4>Patent foramen ovale (PFO)-associated strokes comprise approximately 10% of ischemic strokes in adults aged 18 to 60 years. While device closure decreases stroke recurrence risk overall, the best treatment for any individual is often unclear.<h4>Objective</h4>To evaluate heterogeneity of treatment effect of PFO closure on stroke recurrence based on previously developed scoring systems.<h4>Design, setting, and participants</h4>Investigators for the Systematic, Collaborative, PFO Closure Evaluation (SCOPE) Consortium pooled individual patient data from all 6 randomized clinical trials that compared PFO closure plus medical therapy vs medical therapy alone in patients with PFO-associated stroke, and included a total of 3740 participants. The trials were conducted worldwide 2021-01-01T00:00:00Z2021 Dec2025-05-18T12:49:54.323Z2025-04-06T09:05:10.218ZS-EPMC86722313490503010.1001/jama.2021.20956