{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(12)"],"submitter":["Tung TT"],"pubmed_abstract":["Herein, we demonstrate that 2-difluoromethylpyridine is a bioisosteric replacement of pyridine-<i>N</i>-oxide. Using the quorum sensing inhibitor <b>4NPO</b> as a model compound, a library of 2-difluoromethylpyridine derivatives was designed, synthesized, and evaluated toward quorum sensing activity, biofilm formation, anti-violacein activity, and protease activity. As a result, compounds 1 (IC<sub>50</sub> of 35 ± 1.12 μM), 5 (IC<sub>50</sub> of 19 ± 1.01 μM), and 6 (IC<sub>50</sub> of 27 ± 0.67 μM) showed a similar or better activity in comparison to <b>4NPO</b> (IC<sub>50</sub> of 33 ± 1.12 μM) in a quorum sensing system of <i>Pseudomonas aeruginosa</i>. In addition, compounds 1, 5, 6, and <b>4NPO</b> showed good antibiofilm biomass of <i>Pseudomonas aeruginosa</i> and reduced violacein"],"journal":["RSC medicinal chemistry"],"pagination":["2065-2070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8672814"],"repository":["biostudies-literature"],"pubmed_title":["2-Difluoromethylpyridine as a bioisosteric replacement of pyridine-<i>N</i>-oxide: the case of quorum sensing inhibitors."],"pmcid":["PMC8672814"],"pubmed_authors":["Nguyen Quoc T","Tung TT"],"additional_accession":[]},"is_claimable":false,"name":"2-Difluoromethylpyridine as a bioisosteric replacement of pyridine-<i>N</i>-oxide: the case of quorum sensing inhibitors.","description":"Herein, we demonstrate that 2-difluoromethylpyridine is a bioisosteric replacement of pyridine-<i>N</i>-oxide. Using the quorum sensing inhibitor <b>4NPO</b> as a model compound, a library of 2-difluoromethylpyridine derivatives was designed, synthesized, and evaluated toward quorum sensing activity, biofilm formation, anti-violacein activity, and protease activity. As a result, compounds 1 (IC<sub>50</sub> of 35 ± 1.12 μM), 5 (IC<sub>50</sub> of 19 ± 1.01 μM), and 6 (IC<sub>50</sub> of 27 ± 0.67 μM) showed a similar or better activity in comparison to <b>4NPO</b> (IC<sub>50</sub> of 33 ± 1.12 μM) in a quorum sensing system of <i>Pseudomonas aeruginosa</i>. In addition, compounds 1, 5, 6, and <b>4NPO</b> showed good antibiofilm biomass of <i>Pseudomonas aeruginosa</i> and reduced violacein","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-08T11:35:42.82Z","creation":"2024-11-07T03:41:13.846Z"},"accession":"S-EPMC8672814","cross_references":{"pubmed":["35028565"],"doi":["10.1039/d1md00245g"]}}