{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strawn JR"],"funding":["NICHD NIH HHS"],"pagination":["292-300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8674898"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["298(Pt A)"],"pubmed_abstract":["<h4>Background</h4>Treatment studies of children and adolescents with internalizing disorders suggest that the combination of a selective serotonin reuptake inhibitor (SSRI) and cognitive behavioral therapy (CBT) consistently produces greater improvement than either treatment alone. We sought to determine how response to combined treatment varies across disorders (anxiety versus depression), and by specific patient characteristics.<h4>Methods</h4>Three large National Institutes of Health-funded trials of children and adolescents with major depression (n = 2) and anxiety disorders (n = 1) were evaluated, each comparing CBT + SSRI to SSRI only, Bayesian Hierarchical Models (BHMs) were used, for endpoint response, time course of response and predictors of response in participants who received"],"journal":["Journal of affective disorders"],"pubmed_title":["Combining selective serotonin reuptake inhibitors and cognitive behavioral therapy in youth with depression and anxiety."],"pmcid":["PMC8674898"],"funding_grant_id":["R01 HD098757","R01 HD099775"],"pubmed_authors":["Peris TS","Croarkin PE","Strawn JR","Suresh V","Walkup JT","Mills JA"],"additional_accession":[]},"is_claimable":false,"name":"Combining selective serotonin reuptake inhibitors and cognitive behavioral therapy in youth with depression and anxiety.","description":"<h4>Background</h4>Treatment studies of children and adolescents with internalizing disorders suggest that the combination of a selective serotonin reuptake inhibitor (SSRI) and cognitive behavioral therapy (CBT) consistently produces greater improvement than either treatment alone. We sought to determine how response to combined treatment varies across disorders (anxiety versus depression), and by specific patient characteristics.<h4>Methods</h4>Three large National Institutes of Health-funded trials of children and adolescents with major depression (n = 2) and anxiety disorders (n = 1) were evaluated, each comparing CBT + SSRI to SSRI only, Bayesian Hierarchical Models (BHMs) were used, for endpoint response, time course of response and predictors of response in participants who received","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-26T13:23:47.209Z","creation":"2025-04-06T14:13:48.595Z"},"accession":"S-EPMC8674898","cross_references":{"pubmed":["34728290"],"doi":["10.1016/j.jad.2021.10.047"]}}