{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haukvik UK"],"funding":["NIBIB NIH HHS","NIA NIH HHS","NIMH NIH HHS","National Institutes of Health","Canadian Institutes of Health Research","Generalitat de Catalunya","Deutsche Forschungsgemeinschaft","Instituto de Salud Carlos III","Dutch Research Council (NWO)","Fundação de Amparo à Pesquisa do Estado de São Paulo","AstraZeneca","NIH HHS","Nova Scotia Health Research Foundation","European Social Fund","Brain and Behavior Research Foundation","ZonMw","National Institute of General Medical Sciences","CIHR","Singapore Bioimaging Consortium","William K. Warren Foundation","Health Research Board","National Health and Medical Research Council","National Institute of Mental Health","Helse Sør-Øst RHF","Wellcome Trust","NIGMS NIH HHS"],"pagination":["385-398"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8675404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(1)"],"pubmed_abstract":["The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d"],"journal":["Human brain mapping"],"pubmed_title":["In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group."],"pmcid":["PMC8675404"],"funding_grant_id":["R01 MH117601","2017112","2017SGR1271","016.126.059","2017097","R01MH116147","T32 AG058507","U54 EB020403","U54EB020403","NE 2254/1‐2","R01 AG059874","APP1156072","MSII16/00018","142255","P20GM121312","T32 MH073526","CD16/00264","KI 588/14‐2","KI 588/14‐1","T32AG058507","DA 1151/5‐2","DA 1151/5‐1","R21MH113871","103703","HRA-POR-324","100‐002‐034","2014097","KO 4291/3‐1","R01MH117601","R01AG059874","RP C‐009/2006","R01 MH116147","104036/Z/14/Z","FOR2107","KR 3822/7‐2","1059660","SFB‐TRR58","PI18/00810","5T32MH073526","PI18/00877","P20 GM121312","R21 MH113871","106469","CD18/00029","HRA‐POR‐324","KR 3822/5‐1"],"pubmed_authors":["Hajek T","Foley SF","Repple J","Baune BT","Canales-Rodriguez EJ","Bauer J","Vieta E","Hulsmann C","Delvecchio G","Alnaes D","Malt UF","Ching CRK","Haarman BCM","Grotegerd D","Brambilla P","Rive MM","Pineda-Zapata JA","Westlye LT","Mitchell PB","Ruhe HG","Kramer B","Alda M","Cannon DM","Gruber O","Krug A","Lagerberg TV","Lonning V","Lancaster TM","Nenadic I","Sarro S","Diaz-Zuluaga AM","Stein F","Samann PG","Benedetti F","Fullerton JM","Salminen LE","Salvador R","Jorgensen KN","Dandash O","Hallahan B","Berk M","Goikolea JM","Lenroot RK","Stein DJ","Dannlowski U","Agartz I","Caseras X","Overs BJ","Rauer L","van Erp TGM","Roberts G","Schene AH","Boen E","Otaduy MCG","Whalley HC","Temmingh HS","Andreassen OA","Nerland S","Bonnin CM","Fatjo-Vilas M","Haatveit B","McDonald C","Alonso-Lana S","Tamnes CK","Melle I","Bettella F","Oldani L","Waltemate L","Soeiro-de-Souza MG","Oertel V","Thompson PM","Opel N","Melloni EMT","Stablein M","Haukvik UK","Savitz J","Forster K","Gurholt TP","Howells FM","Pomarol-Clotet E","Nabulsi L","McIntosh AM","Radua J","Elvsashagen T","Sim K","Harris M","Jahanshad N","Veltman DJ","Hawkins EL","Lopez-Jaramillo C","McPhilemy G","Akudjedu TN","Kuplicki R","Redlich R","Thomopoulos SI","van der Meer D","ENIGMA Bipolar Disorder Working Group","Kircher T"],"additional_accession":[]},"is_claimable":false,"name":"In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.","description":"The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-22T22:03:22.343Z","creation":"2025-04-06T03:54:09.025Z"},"accession":"S-EPMC8675404","cross_references":{"pubmed":["33073925"],"doi":["10.1002/hbm.25249"]}}