{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Zwarte SMC"],"funding":["NIBIB NIH HHS","NIA NIH HHS","NIMH NIH HHS","National Institutes of Health","Canadian Institutes of Health Research","National Institute on Aging","Ministerstvo Zdravotnictví Ceské Republiky","Generalitat de Catalunya","National Centre of Competence in Research Robotics","Deutsche Forschungsgemeinschaft","Instituto de Salud Carlos III","National Institute for Health Research (NIHR)","NINDS NIH HHS","NIH HHS","Medical Research Council Canada","Vetenskapsrådet","Stanley Medical Research Institute","ZonMw","VA","CSRD VA","CIHR","Norges Forskningsråd","Swiss National Science Foundation","National Alliance for Research on Schizophrenia and Depression","Medical Research Council","National Institute of Mental Health","Wellcome Trust"],"pagination":["414-430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8675411"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(1)"],"pubmed_abstract":["First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs "],"journal":["Human brain mapping"],"pubmed_title":["Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder."],"pmcid":["PMC8675411"],"funding_grant_id":["R01 MH117601","S10 OD017974","T32 AG058507","R01 MH118695","PI070066","PDA/02/06/016","I01 CX000227","R01 MH080912","223273","1617","R03 MH105808","R01 MH111671","106469, 142255","NT13891","PI18/00976","NR8786","085475/Z/08/Z","R01 MH113619","1S10OD017974‐01","R01MH121246","R01 MH052857","K2007‐62X‐15077‐04‐1","R01 MH085667","P41 EB027061","K2012‐61X‐15078‐09‐3","U01 MH108150","2017SGR01271","I01CX000227","U54 EB020403","U54EB020403","1S10OD017974-01","G0801418B","P30 NS076408","K2010‐62X‐15078‐07‐2","R01 MH121246","MR/L010305/1","T32AG058507","085475/B/08/Z","103703","064971","P41 EB015922","G0801418","CPII19/00009","091630","908‐02‐123","156914","PI1500467","NIHR200756","R01 MH116147","32003B_156914","51NF40‐185897","17319","PI1100683","K2008‐62P‐20597‐01‐3","20244, 26731","G0901310"],"pubmed_authors":["Hajek T","Wu MJ","Kahn RS","Johansson V","Bearden CE","Foley SF","Fears SC","Soares JC","Olman CA","Murray RM","Canales-Rodriguez EJ","Vieta E","Di Giorgio A","Kane F","Buimer EEL","Ching CRK","Simsek F","Chung Y","de Zwarte SMC","Saricicek Aydogan A","Walter H","Gonul AS","Mitchell PB","Picchioni MM","Kramer B","Kempton MJ","Kopecek M","Bonvino A","Alda M","Cannon DM","Gruber O","Moreno D","Ozerdem A","Mattay VS","Pergola G","Sarro S","Brouwer RM","Glahn DC","Del Mar Bonnin C","Fullerton JM","Michielse S","Hidiroglu Ongun C","Salvador R","Hulshoff Pol HE","Hultman CM","Goikolea JM","Lenroot RK","Schofield PR","Piguet C","Agartz I","Caseras X","Overs BJ","van Erp TGM","Cannon TD","Roberts G","Goghari VM","Ingvar M","Lawrie SM","Eker MC","De la Serna E","Whalley HC","Andreassen OA","Fatjo-Vilas M","Koenis MMG","McDonald C","Chen Q","Alonso-Lana S","Doucet GE","Bramon E","van Os J","Goldman AL","Demro C","Hillegers MHJ","Thompson PM","Bertolino A","Frangou S","Heinz A","Newport J","van Haren NEM","Houenou J","Pomarol-Clotet E","Tronchin G","Nabulsi L","Simsek EM","Radua J","Meyer-Lindenberg A","Richter A","Castro-Fornieles J","Yalin N","Jahanshad N","Cahn W","Hawkins EL","Ramsay IS","Erk S","Sponheim SR","Marcelis M","Thomopoulos SI","Weinberger DR","Jonsson EG","Sugranyes G","Toulopoulou T","Mwangi B"],"additional_accession":[]},"is_claimable":false,"name":"Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.","description":"First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-22T22:02:51.398Z","creation":"2025-04-06T03:53:54.569Z"},"accession":"S-EPMC8675411","cross_references":{"pubmed":["33027543"],"doi":["10.1002/hbm.25206"]}}