biostudies-literaturede Zwarte SMCNIBIB NIH HHSNIA NIH HHSNIMH NIH HHSNational Institutes of HealthCanadian Institutes of Health ResearchNational Institute on AgingMinisterstvo Zdravotnictví Ceské RepublikyGeneralitat de CatalunyaNational Centre of Competence in Research RoboticsDeutsche ForschungsgemeinschaftInstituto de Salud Carlos IIINational Institute for Health Research (NIHR)NINDS NIH HHSNIH HHSMedical Research Council CanadaVetenskapsrådetStanley Medical Research InstituteZonMwVACSRD VACIHRNorges ForskningsrådSwiss National Science FoundationNational Alliance for Research on Schizophrenia and DepressionMedical Research CouncilNational Institute of Mental HealthWellcome Trust414-430https://www.ebi.ac.uk/biostudies/studies/S-EPMC8675411biostudies-literatureUnknown43(1)First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs Human brain mappingIntelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.PMC8675411R01 MH117601S10 OD017974T32 AG058507R01 MH118695PI070066PDA/02/06/016I01 CX000227R01 MH0809122232731617R03 MH105808R01 MH111671106469, 142255NT13891PI18/00976NR8786085475/Z/08/ZR01 MH1136191S10OD017974‐01R01MH121246R01 MH052857K2007‐62X‐15077‐04‐1R01 MH085667P41 EB027061K2012‐61X‐15078‐09‐3U01 MH1081502017SGR01271I01CX000227U54 EB020403U54EB0204031S10OD017974-01G0801418BP30 NS076408K2010‐62X‐15078‐07‐2R01 MH121246MR/L010305/1T32AG058507085475/B/08/Z103703064971P41 EB015922G0801418CPII19/00009091630908‐02‐123156914PI1500467NIHR200756R01 MH11614732003B_15691451NF40‐18589717319PI1100683K2008‐62P‐20597‐01‐320244, 26731G0901310Hajek TWu MJKahn RSJohansson VBearden CEFoley SFFears SCSoares JCOlman CAMurray RMCanales-Rodriguez EJVieta EDi Giorgio AKane FBuimer EELChing CRKSimsek FChung Yde Zwarte SMCSaricicek Aydogan AWalter HGonul ASMitchell PBPicchioni MMKramer BKempton MJKopecek MBonvino AAlda MCannon DMGruber OMoreno DOzerdem AMattay VSPergola GSarro SBrouwer RMGlahn DCDel Mar Bonnin CFullerton JMMichielse SHidiroglu Ongun CSalvador RHulshoff Pol HEHultman CMGoikolea JMLenroot RKSchofield PRPiguet CAgartz ICaseras XOvers BJvan Erp TGMCannon TDRoberts GGoghari VMIngvar MLawrie SMEker MCDe la Serna EWhalley HCAndreassen OAFatjo-Vilas MKoenis MMGMcDonald CChen QAlonso-Lana SDoucet GEBramon Evan Os JGoldman ALDemro CHillegers MHJThompson PMBertolino AFrangou SHeinz ANewport Jvan Haren NEMHouenou JPomarol-Clotet ETronchin GNabulsi LSimsek EMRadua JMeyer-Lindenberg ARichter ACastro-Fornieles JYalin NJahanshad NCahn WHawkins ELRamsay ISErk SSponheim SRMarcelis MThomopoulos SIWeinberger DRJonsson EGSugranyes GToulopoulou TMwangi BfalseIntelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs 2022-01-01T00:00:00Z2022 Jan2025-04-22T22:02:51.398Z2025-04-06T03:53:54.569ZS-EPMC86754113302754310.1002/hbm.25206