{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Lu S"],"pubmed_abstract":["As alternatives to antibiotics in feed, probiotic <i>Bacillus</i> carries multiple advantages in animal production. Spores undergo strain-related germination in the gastrointestinal tract, but it is still unknown whether the probiotic function of the <i>Bacillus</i> depends on the germination of spores <i>in vivo</i>. In this study, based on 14 potential probiotic <i>Bacillus</i> strains from fermented food and feed, we detected the germination response of these <i>Bacillus</i> spores in relation to different germinating agents. The results showed the germination response was strain-specific and germinant-related, and nutrient germinant L-alanine significantly promoted the growth of strains with germination potential. Two strains of <i>Bacillus subtilis</i>, S-2 and 312, with or without a "],"journal":["Frontiers in microbiology"],"pagination":["796158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8675871"],"repository":["biostudies-literature"],"pubmed_title":["Nutrient L-Alanine-Induced Germination of <i>Bacillus</i> Improves Proliferation of Spores and Exerts Probiotic Effects <i>in vitro</i> and <i>in vivo</i>."],"pmcid":["PMC8675871"],"pubmed_authors":["Fang Y","Liao X","Guo X","Lu S","Zhang L","Xiang M"],"additional_accession":[]},"is_claimable":false,"name":"Nutrient L-Alanine-Induced Germination of <i>Bacillus</i> Improves Proliferation of Spores and Exerts Probiotic Effects <i>in vitro</i> and <i>in vivo</i>.","description":"As alternatives to antibiotics in feed, probiotic <i>Bacillus</i> carries multiple advantages in animal production. Spores undergo strain-related germination in the gastrointestinal tract, but it is still unknown whether the probiotic function of the <i>Bacillus</i> depends on the germination of spores <i>in vivo</i>. In this study, based on 14 potential probiotic <i>Bacillus</i> strains from fermented food and feed, we detected the germination response of these <i>Bacillus</i> spores in relation to different germinating agents. The results showed the germination response was strain-specific and germinant-related, and nutrient germinant L-alanine significantly promoted the growth of strains with germination potential. Two strains of <i>Bacillus subtilis</i>, S-2 and 312, with or without a ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-03-16T16:02:48.382Z","creation":"2025-06-01T03:45:54.199Z"},"accession":"S-EPMC8675871","cross_references":{"pubmed":["34925306"],"doi":["10.3389/fmicb.2021.796158"]}}