{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pascoal TA"],"funding":["Weston Brain Institute","Alzheimer’s Association","Fonds de Recherche du Québec – Santé","Brain Canada Foundation","National Institute of Aging","NIA NIH HHS","Canadian Consortium of Neurodegeneration and Aging","Alzheimer's Association","Canadian Institutes of Health Research","CIHR"],"pagination":["3517-3528"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8677534"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(11)"],"pubmed_abstract":["Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology and for clinical trials. Although the available first-generation tau PET tracers detect tau accumulation in symptomatic individuals, their nanomolar affinity offers limited sensitivity to detect early tau accumulation in asymptomatic subjects. Here, we hypothesized the novel subnanomolar affinity tau tangles tracer 18F-MK-6240 can detect longitudinal tau accumulation in asymptomatic and symptomatic subjects. We studied 125 living individuals (65 cognitively unimpaired elderly amyloid-β-negative, 22 cognitively unimpaired elderly amyloid-β-positive, 21 mild cognitive impairment amyloid-β-positive and 17 Alzheimer's disease dementia amyl"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages."],"pmcid":["PMC8677534"],"funding_grant_id":["159815","162303","R01 AG073267","NIRP-12-259245","2020-VICO-279314","MOP-11-51-31 -team 1","R01AG073267","NIRG-12-92090","RFN 152985","MOP-11-51-31","34874","33397","AACSF-20–648075"],"pubmed_authors":["Kang MS","Gauthier S","Rosa-Neto P","Tudorascu DL","Tissot C","Mathotaarachchi S","Stevenson J","Soucy JP","Chamoun M","Pascoal TA","Benedet AL","Guiot MC","Therriault J","Savard M","Lussier FZ","Massarweh G"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.","description":"Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology and for clinical trials. Although the available first-generation tau PET tracers detect tau accumulation in symptomatic individuals, their nanomolar affinity offers limited sensitivity to detect early tau accumulation in asymptomatic subjects. Here, we hypothesized the novel subnanomolar affinity tau tangles tracer 18F-MK-6240 can detect longitudinal tau accumulation in asymptomatic and symptomatic subjects. We studied 125 living individuals (65 cognitively unimpaired elderly amyloid-β-negative, 22 cognitively unimpaired elderly amyloid-β-positive, 21 mild cognitive impairment amyloid-β-positive and 17 Alzheimer's disease dementia amyl","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-03-31T10:59:07.142Z","creation":"2025-04-06T07:41:02.344Z"},"accession":"S-EPMC8677534","cross_references":{"pubmed":["34515754"],"doi":["10.1093/brain/awab248"]}}