{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang W"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","National Institutes of Health"],"pagination":["150-165"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8678294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["162(1)"],"pubmed_abstract":["<h4>Background & aims</h4>G protein-coupled receptor (GPR) 120 has been implicated in regulating metabolic syndromes with anti-inflammatory function. However, the role of GPR120 in intestinal inflammation is unknown. Here, we investigated whether and how GPR120 regulates CD4<sup>+</sup> T cell function to inhibit colitis development.<h4>Methods</h4>Dextran sodium sulfate (DSS)-induced colitis model, Citrobacter rodentium infection model, and CD4<sup>+</sup> T cell adoptive transfer model were used to analyze the role of GPR120 in regulating colitis development. The effect of GPR120 on CD4<sup>+</sup> T cell functions was analyzed by RNA sequencing, flow cytometry, and Seahorse metabolic assays. Mice were administered GPR120 agonist for investigating the potential of GPR120 agonist in preve"],"journal":["Gastroenterology"],"pubmed_title":["GPR120 Inhibits Colitis Through Regulation of CD4<sup>+</sup> T Cell Interleukin 10 Production."],"pmcid":["PMC8678294"],"funding_grant_id":["R21 AI150210","R01 DK125011","R01 DK124132"],"pubmed_authors":["Liu H","Xu L","Zhang H","Zuo X","Yao S","Barnes S","Zhao X","Yang W","Li Y","Dann SM","Zhao Q","Yu T","Cong Y","Cohn SM"],"additional_accession":[]},"is_claimable":false,"name":"GPR120 Inhibits Colitis Through Regulation of CD4<sup>+</sup> T Cell Interleukin 10 Production.","description":"<h4>Background & aims</h4>G protein-coupled receptor (GPR) 120 has been implicated in regulating metabolic syndromes with anti-inflammatory function. However, the role of GPR120 in intestinal inflammation is unknown. Here, we investigated whether and how GPR120 regulates CD4<sup>+</sup> T cell function to inhibit colitis development.<h4>Methods</h4>Dextran sodium sulfate (DSS)-induced colitis model, Citrobacter rodentium infection model, and CD4<sup>+</sup> T cell adoptive transfer model were used to analyze the role of GPR120 in regulating colitis development. The effect of GPR120 on CD4<sup>+</sup> T cell functions was analyzed by RNA sequencing, flow cytometry, and Seahorse metabolic assays. Mice were administered GPR120 agonist for investigating the potential of GPR120 agonist in preve","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-21T14:26:58.01Z","creation":"2025-02-18T22:34:23.376Z"},"accession":"S-EPMC8678294","cross_references":{"pubmed":["34536451"],"doi":["10.1053/j.gastro.2021.09.018"]}}