biostudies-literatureNorris TMedical Research CouncilNational Institute for Health Research (NIHR)HDR-UKWellcome TrustUKRI-DHSC1200-1208https://www.ebi.ac.uk/biostudies/studies/S-EPMC8678560biostudies-literatureUnknown108(15)<h4>Objective</h4>Using a large national database of people hospitalised with COVID-19, we investigated the contribution of cardio-metabolic conditions, multi-morbidity and ethnicity on the risk of in-hospital cardiovascular complications and death.<h4>Methods</h4>A multicentre, prospective cohort study in 302 UK healthcare facilities of adults hospitalised with COVID-19 between 6 February 2020 and 16 March 2021. Logistic models were used to explore associations between baseline patient ethnicity, cardiometabolic conditions and multimorbidity (0, 1, 2, >2 conditions), and in-hospital cardiovascular complications (heart failure, arrhythmia, cardiac ischaemia, cardiac arrest, coagulation complications, stroke), renal injury and death.<h4>Results</h4>Of 65 624 patients hospitalised with COVIDHeart (British Cardiac Society)Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19.PMC8678560MR/P011705/2MR/P011705/1RP-2017-08-ST2-007NIHR300669MC_UP_A090_1006MC_PC_19025MC_PC_19059MR/S032304/1NIHR300111HDRUK2021.0125216606/Z/19/ZCO-CIN-01MR/V020536/1HDRUK2020.138Williams MMeda MBach BSancho-Shimizu VDrummond ALeiner TMortimore KPatel BCarlucci NLittle JMaziere NDouthwaite SRae NVincent-Smith LBogaert DKiy CKKlenerman PKaliappan APaxton WALillie PJain SHartley CKendall JCosgrove CMankregod RFinn AFletcher TSilva TShaw VERambaut AYoung PCaruth VPost FKegg SLimb JWaddy SPapakonstantinou DCarson GJensen RLChechi KMarsh LDocherty ABAhmed KASummers CNagarajan TPooni JSMassey HTurtle LCClarke EAEve Wilcock JBothma PWootton DGKnight SRSales DLatawiec DAndrikopoulos PTatham KSemple MGKasipandian VLivoti LAPais MHorby PWPintus SPius RWaiHo AYHartshorn SMcCullough KVuylsteke AMclean KAIjaz SMirfenderesky MGarcia-Dorival IISARIC4C investigatorsCollini PTakis PTonder LVThompson CDrake TMRoberts SLaird SGunning PBeadsworth MPhull MPepperell JSaluja TSnelson CLinnett VArmstrong JAMcDonald SHormis AMills GSharma ATrochu EAgwuh KZambon MDavis CShaw CALiggi SSriskandan SKoch OPeters MEvans AGreenhalf WRousseau GMok QEvans CWiselka MGreen CASzemiel ANelson MGupta RKLett LLant SMcDonald SEAldera ELMacNaughton EDunn CChukkambotla SCorreia GDSOtahal IMoon JIslam NMinton JPollakis GTedder RSMorris CThomson ECSwann OVAtkinson DHalpin SCarracedo ADFlaherty LLeeming GCooke GSCutino-Moguel MTBasude SEziefula CRoger Thompson AAMurphy MParaiso HJackson CRidley MMeynert AMLam CSPStaines NScott-Brown JFisher LWFairfield CJSizer JPapineni PAgranoff DChee NOlanipekun MMatovu ESubramaniam KSThompson RVallotton NPilgrim JMancini MPanchatsharam SKhoo SKerslake IPattison NHardwick HGriffiths FMoore SCMoore EOosthuyzen WBulteel NMoses SCooper LTaggart AMulla RTwagira MZhang EMatthew KWake RNoursadeghi MWilson LBassford CBaxter DKenneth Baillie JPrince TLarkin SZaccardi FWijesinghe MBakshi SLefteri DKerrison CPalmarini MRichardson NConnor MKoduri GLim WSHawcutt DBGriffin JLLake AMcEvoy LWelters IOsagie AMurphy DStambach TSolomon TDyer PRyan BDyer TWill Reynolds PDervisevic SLaha SChambler DTupper-Carey DMpenge MClark TAsiimwe IGAdeniji KClohisey SDalton JBarlow SLJones TRWorkman AWhittington ARazieh CScott JTWhittaker PThomas JJacobs MDunning JShankar-Hari MNorris TPalmieri CMohandas KGillies CLBooth LBest NNorris LHendry RSaviciute ECole STanianis-Hughes JKhunti KMentzer AJDawson CFegan CTakats ZBerridge JGoldsmith AMitchell JMerson LReynolds TPrice NSmall BShaw VStewart RShanmuga PBullock KJones CBCox HFullerton DSands CJCupitt JRoberts DDonnison PHiscox JAMaslen LRoberts MBurtenshaw APrice DBurden TDumas MELaw ABrittain-Long RKelsey MBaillie JKSzakmany TClark JJHavalda PMiddleton JKeating SKoshy GAshish AGodden JHodgson LJennings PKhandaker SChadwick DYates TAil DTridente ANagel MBarlow GHolmes AChild JWham MGarg SLawson CAChand MElliott AHobrok MMcEwen RFoster TDuRand IOpenshaw PJRussell CDMcCann GPGarg ABari SLewis MRPenrice-Randal RGraham CRowlands AVRobertson DLThwaites RSGamble CBarclay WSDavies MJBrennan BWinchester SSubudhi PDincarslan OHarrison EMBernatoniene JVancheeswaran RHarvey DMacMahon MYates BReschreiter HWolverson AShears RKBarnass SChudasama YVBanerjee AHardy ENorman LProut RMcLauchlan JMiah NSWalden ADark PFilipe ADSKing KVisuvanathan SSpittle NHarrison JO'Shea MOMurphy EGBarrett NFinch LLyttle MCass EMetelmann SMasson HRobyn TDushianthan ACatterall BWGkrania-Klotsas ELavelle-Langham LAlex BAshworth MRose AShawcross AAlegria AWhitehouse TShah AGirvan MAngus BSmith RSigfrid LDonohue CMorgan PfalseImpact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19.<h4>Objective</h4>Using a large national database of people hospitalised with COVID-19, we investigated the contribution of cardio-metabolic conditions, multi-morbidity and ethnicity on the risk of in-hospital cardiovascular complications and death.<h4>Methods</h4>A multicentre, prospective cohort study in 302 UK healthcare facilities of adults hospitalised with COVID-19 between 6 February 2020 and 16 March 2021. Logistic models were used to explore associations between baseline patient ethnicity, cardiometabolic conditions and multimorbidity (0, 1, 2, >2 conditions), and in-hospital cardiovascular complications (heart failure, arrhythmia, cardiac ischaemia, cardiac arrest, coagulation complications, stroke), renal injury and death.<h4>Results</h4>Of 65 624 patients hospitalised with COVID2022-01-01T00:00:00Z2022 Jul2026-07-15T00:47:19.144Z2026-06-27T03:04:57.888ZS-EPMC86785603491174110.1136/heartjnl-2021-320047