{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang M"],"funding":["national natural science foundation of china","jiangsu province’s key discipline of medicine","the priority academic program development of jiangsu higher education institutions"],"pagination":["116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8684143"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic.<h4>Methods</h4>We used TNBC cells and xenografted mice as models to explore triptonide-mediated inhibition of TNBC metastasis and tumor growth. Colony formation assay was used to quantify the tumorigenesis of TNBC cells. Wound-healing and cell trans-well assays were utilized to measure cell migration and invasion. Tube formation assay was applied to access tumor cell-mediated vasculogenic mimicry. Western blot, quantitative-PCR, immunofluorescence imaging, and immunohistochemical staining were used to measure the expression levels of various tumorigenic genes in TNBC cells.<h4>Results</h4>Here, we showe"],"journal":["Breast cancer research : BCR"],"pubmed_title":["Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins."],"pmcid":["PMC8684143"],"funding_grant_id":["XK201118","No.81902647","No.82073225","No. 81703595","No. 81772535"],"pubmed_authors":["Liu Y","Qiao Y","Qi J","Hu Y","Lu W","Xu P","Zhou Q","Meng M","Zhang M","Zhao Z","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins.","description":"<h4>Background</h4>Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic.<h4>Methods</h4>We used TNBC cells and xenografted mice as models to explore triptonide-mediated inhibition of TNBC metastasis and tumor growth. Colony formation assay was used to quantify the tumorigenesis of TNBC cells. Wound-healing and cell trans-well assays were utilized to measure cell migration and invasion. Tube formation assay was applied to access tumor cell-mediated vasculogenic mimicry. Western blot, quantitative-PCR, immunofluorescence imaging, and immunohistochemical staining were used to measure the expression levels of various tumorigenic genes in TNBC cells.<h4>Results</h4>Here, we showe","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-07T21:17:34.576Z","creation":"2022-02-11T14:11:13.243Z"},"accession":"S-EPMC8684143","cross_references":{"pubmed":["34922602"],"doi":["10.1186/s13058-021-01488-7"]}}