{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["225(3)"],"submitter":["Ryan KA"],"funding":["AstraZeneca"],"pubmed_abstract":["Cocirculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses could pose unpredictable risks to health systems globally, with recent studies suggesting more severe disease outcomes in coinfected patients. The initial lack of a readily available coronavirus disease 2019 (COVID-19) vaccine has reinforced the importance of influenza vaccine programs during the COVID-19 pandemic. Live attenuated influenza vaccine (LAIV) is an important tool in protecting against influenza, particularly in children. However, it is unknown whether LAIV administration influences the outcomes of acute SARS-CoV-2 infection or disease. To investigate this, quadrivalent LAIV was administered to ferrets 3 days before or after SARS-CoV-2 infection. LAIV administration did not exace"],"journal":["The Journal of infectious diseases"],"pagination":["404-412"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8689863"],"repository":["biostudies-literature"],"pubmed_title":["Sequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology."],"pmcid":["PMC8689863"],"pubmed_authors":["Ryan KA","Rayner E","Watson RJ","Crowe J","Marriott AC","Fotheringham SA","Whittaker CJ","Dibben O","Salguero FJ","Hall Y","Humphreys R","Carroll MW","Paterson J","Schewe KE"],"additional_accession":[]},"is_claimable":false,"name":"Sequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology.","description":"Cocirculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses could pose unpredictable risks to health systems globally, with recent studies suggesting more severe disease outcomes in coinfected patients. The initial lack of a readily available coronavirus disease 2019 (COVID-19) vaccine has reinforced the importance of influenza vaccine programs during the COVID-19 pandemic. Live attenuated influenza vaccine (LAIV) is an important tool in protecting against influenza, particularly in children. However, it is unknown whether LAIV administration influences the outcomes of acute SARS-CoV-2 infection or disease. To investigate this, quadrivalent LAIV was administered to ferrets 3 days before or after SARS-CoV-2 infection. LAIV administration did not exace","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-08T06:26:02.137Z","creation":"2026-04-07T23:41:40.478Z"},"accession":"S-EPMC8689863","cross_references":{"pubmed":["34893851"],"doi":["10.1093/infdis/jiab594"]}}