{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kreft IC"],"funding":["NIAID NIH HHS","NINDS NIH HHS"],"pagination":["6-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8690567"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["210"],"pubmed_abstract":["<h4>Background</h4>Many patients who are diagnosed with coronavirus disease 2019 (COVID-19) suffer from venous thromboembolic complications despite the use of stringent anticoagulant prophylaxis. Studies on the exact mechanism(s) underlying thrombosis in COVID-19 are limited as animal models commonly used to study venous thrombosis pathophysiology (i.e. rats and mice) are naturally not susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Ferrets are susceptible to SARS-CoV-2 infection, successfully used to study virus transmission, and have been previously used to study activation of coagulation and thrombosis during influenza virus infection.<h4>Objectives</h4>This study aimed to explore the use of (heat-inactivated) plasma and lung material from SARS-CoV-2-inocula"],"journal":["Thrombosis research"],"pubmed_title":["Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model."],"pmcid":["PMC8690567"],"funding_grant_id":["R01 AI121349","R01 NS091263","R56 AI146980"],"pubmed_authors":["Schmitz KS","Hoogendijk AJ","Kreft IC","Salvatori DCF","Tanis FJ","van der Zwaan C","van Vlijmen BJM","Porotto M","Winiarczyk RRA","de Vries RD","Moscona A","Dutch Covid-19 and Thrombosis Coalition (DCTC)","de Swart RL","de Maat MPM","van den Biggelaar M"],"additional_accession":[]},"is_claimable":false,"name":"Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model.","description":"<h4>Background</h4>Many patients who are diagnosed with coronavirus disease 2019 (COVID-19) suffer from venous thromboembolic complications despite the use of stringent anticoagulant prophylaxis. Studies on the exact mechanism(s) underlying thrombosis in COVID-19 are limited as animal models commonly used to study venous thrombosis pathophysiology (i.e. rats and mice) are naturally not susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Ferrets are susceptible to SARS-CoV-2 infection, successfully used to study virus transmission, and have been previously used to study activation of coagulation and thrombosis during influenza virus infection.<h4>Objectives</h4>This study aimed to explore the use of (heat-inactivated) plasma and lung material from SARS-CoV-2-inocula","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-06-01T01:16:24.441Z","creation":"2024-11-13T21:56:03.43Z"},"accession":"S-EPMC8690567","cross_references":{"pubmed":["34954402"],"doi":["10.1016/j.thromres.2021.12.015"]}}