biostudies-literatureKreft ICNIAID NIH HHSNINDS NIH HHS6-11https://www.ebi.ac.uk/biostudies/studies/S-EPMC8690567biostudies-literatureUnknown210<h4>Background</h4>Many patients who are diagnosed with coronavirus disease 2019 (COVID-19) suffer from venous thromboembolic complications despite the use of stringent anticoagulant prophylaxis. Studies on the exact mechanism(s) underlying thrombosis in COVID-19 are limited as animal models commonly used to study venous thrombosis pathophysiology (i.e. rats and mice) are naturally not susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Ferrets are susceptible to SARS-CoV-2 infection, successfully used to study virus transmission, and have been previously used to study activation of coagulation and thrombosis during influenza virus infection.<h4>Objectives</h4>This study aimed to explore the use of (heat-inactivated) plasma and lung material from SARS-CoV-2-inoculaThrombosis researchAbsence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model.PMC8690567R01 AI121349R01 NS091263R56 AI146980Schmitz KSHoogendijk AJKreft ICSalvatori DCFTanis FJvan der Zwaan Cvan Vlijmen BJMPorotto MWiniarczyk RRAde Vries RDMoscona ADutch Covid-19 and Thrombosis Coalition (DCTC)de Swart RLde Maat MPMvan den Biggelaar MfalseAbsence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model.<h4>Background</h4>Many patients who are diagnosed with coronavirus disease 2019 (COVID-19) suffer from venous thromboembolic complications despite the use of stringent anticoagulant prophylaxis. Studies on the exact mechanism(s) underlying thrombosis in COVID-19 are limited as animal models commonly used to study venous thrombosis pathophysiology (i.e. rats and mice) are naturally not susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Ferrets are susceptible to SARS-CoV-2 infection, successfully used to study virus transmission, and have been previously used to study activation of coagulation and thrombosis during influenza virus infection.<h4>Objectives</h4>This study aimed to explore the use of (heat-inactivated) plasma and lung material from SARS-CoV-2-inocula2022-01-01T00:00:00Z2022 Feb2025-06-01T01:16:24.441Z2024-11-13T21:56:03.43ZS-EPMC86905673495440210.1016/j.thromres.2021.12.015