biostudies-literatureYang JNational Basic Research Program of ChinaSix Talent Peaks Project in Jiangsu Province164-167https://www.ebi.ac.uk/biostudies/studies/S-EPMC8690850biostudies-literatureUnknown11(1)A Mn(ii)-catalysed <i>ortho</i>-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl₂ was critical for the <i>ortho</i>-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds 3m on 8 week-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 week-old adult male rats with azoospermia with 1 mg kg^-13m after two weeks, while treatment with 10 mg kg^-13m led to obviRSC advancesMn(ii)-Catalysed <i>ortho</i>-alkenylation of aromatic amines and its application in reproductive diseases.PMC86908502018YFC1003500131219631004Liu YYang JCheng RYang BSun FGong ZWu XfalseMn(ii)-Catalysed <i>ortho</i>-alkenylation of aromatic amines and its application in reproductive diseases.A Mn(ii)-catalysed <i>ortho</i>-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl₂ was critical for the <i>ortho</i>-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds 3m on 8 week-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 week-old adult male rats with azoospermia with 1 mg kg^-13m after two weeks, while treatment with 10 mg kg^-13m led to obvi2020-01-01T00:00:00Z2020 Dec2025-04-05T13:07:57.14Z2025-04-05T13:07:57.14ZS-EPMC86908503542306510.1039/d0ra10172a