{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ling X"],"funding":["Guizhou University"],"pagination":["7795527"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8692010"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["<h4>Background</h4>Shu-Di-Huang (Radix Rehmanniae Praeparata, RR) and Gan-Cao (liquorice, L) are frequently used traditional Chinese herb pair in treating osteoporosis (OP). However, the exact mechanism of the RR and L herb pair (RR-L) remains unclear. To explore the efficacy and possible mechanisms of RR-L in treating OP, in silico, in vitro, and in vivo experiments were conducted in the current study.<h4>Methods</h4>In silico, potential therapeutic target genes and active chemical compounds of RR-L herb pair were predicted and constructed into a network. In vivo, 30 Sprague Dawley rats were divided into 3 groups, including the sham group, the OP model group, and the RR-L-treated OP group. Micro-CT and pathological sections were conducted to validate the therapeutic effects of RR-L in tre"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Shu-Di-Huang and Gan-Cao Herb Pair Restored the Differentiation Potentials of Mesenchymal Stem Progenitors in Treating Osteoporosis via Downregulation of NF-<i>κ</i>B Signaling Pathway."],"pmcid":["PMC8692010"],"funding_grant_id":["5766-02"],"pubmed_authors":["Li J","Zhang T","Ling X","Wang X","Zhou Y","Kang J","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"Shu-Di-Huang and Gan-Cao Herb Pair Restored the Differentiation Potentials of Mesenchymal Stem Progenitors in Treating Osteoporosis via Downregulation of NF-<i>κ</i>B Signaling Pathway.","description":"<h4>Background</h4>Shu-Di-Huang (Radix Rehmanniae Praeparata, RR) and Gan-Cao (liquorice, L) are frequently used traditional Chinese herb pair in treating osteoporosis (OP). However, the exact mechanism of the RR and L herb pair (RR-L) remains unclear. To explore the efficacy and possible mechanisms of RR-L in treating OP, in silico, in vitro, and in vivo experiments were conducted in the current study.<h4>Methods</h4>In silico, potential therapeutic target genes and active chemical compounds of RR-L herb pair were predicted and constructed into a network. In vivo, 30 Sprague Dawley rats were divided into 3 groups, including the sham group, the OP model group, and the RR-L-treated OP group. Micro-CT and pathological sections were conducted to validate the therapeutic effects of RR-L in tre","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-29T21:06:11.659Z","creation":"2025-05-29T21:06:11.659Z"},"accession":"S-EPMC8692010","cross_references":{"pubmed":["34950216"],"doi":["10.1155/2021/7795527"]}}