biostudies-literatureParcha VNHLBI NIH HHSe003353https://www.ebi.ac.uk/biostudies/studies/S-EPMC8692353biostudies-literatureUnknown14(6)<h4>Background</h4>Among patients receiving percutaneous coronary intervention (PCI), the role of a genotype-guided approach for antiplatelet therapy compared with usual care is unclear. We conducted a Bayesian analysis of the entire TAILOR-PCI (Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention) randomized clinical trial population to evaluate the effect of the genotype-guided antiplatelet therapy post-PCI compared with the usual care on the risk of major adverse cardiovascular events (MACE).<h4>Methods</h4>The primary outcome for our study was the composite of MACE (myocardial infarction, stroke, and cardiovascular death). Secondary outcomes included cardiovascular death, stroke, myocardial infarction, stent Circulation. Genomic and precision medicineGenotype-Guided P2Y₁₂ Inhibitor Therapy After Percutaneous Coronary Intervention: A Bayesian Analysis.PMC8692353U01 HL128606K23 HL146887Pereira NLArora PHeindl BFParcha VKalra RLimdi NALi PArora GfalseGenotype-Guided P2Y₁₂ Inhibitor Therapy After Percutaneous Coronary Intervention: A Bayesian Analysis.<h4>Background</h4>Among patients receiving percutaneous coronary intervention (PCI), the role of a genotype-guided approach for antiplatelet therapy compared with usual care is unclear. We conducted a Bayesian analysis of the entire TAILOR-PCI (Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention) randomized clinical trial population to evaluate the effect of the genotype-guided antiplatelet therapy post-PCI compared with the usual care on the risk of major adverse cardiovascular events (MACE).<h4>Methods</h4>The primary outcome for our study was the composite of MACE (myocardial infarction, stroke, and cardiovascular death). Secondary outcomes included cardiovascular death, stroke, myocardial infarction, stent 2021-01-01T00:00:00Z2021 Dec2025-04-04T19:38:16.308Z2025-04-04T19:38:16.308ZS-EPMC86923533467039610.1161/CIRCGEN.121.00335310.1161/circgen.121.003353