{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li S"],"funding":["Fundamental Research Funds for the Central Universities","China University of Geosciences, Beijing","National Natural Science Foundation of China"],"pagination":["671-677"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8693351"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Electrochemical aptamer-based (E-AB) sensors provide a great opportunity towards the goal of point-of-care and wearable sensing technologies due to their good sensitivity and selectivity. Nevertheless, the output signals from this sensor class remain low when sensors are interrogated <i>via</i> square-wave voltammetry. This low signaling limits the sensor's precision for its capability to detect small changes in target concentrations. To circumvent this, we proposed here the use of a readily shrink-induced, wrinkled Au-coating polyolefin film to immobilize a greater number of DNA probes and thus improve the signaling. Specifically, wrinkled gold film exhibits a 5.5-fold increase of surface area in comparison to the unwrinkled ones. Using these substrates we fabricated a set of E-AB sensors"],"journal":["RSC advances"],"pubmed_title":["A wrinkled structure of gold film greatly improves the signaling of electrochemical aptamer-based biosensors."],"pmcid":["PMC8693351"],"funding_grant_id":["21874121","21801231","CUG170668","CUG170665","21804121"],"pubmed_authors":["Li H","Li S","Plaxco KW","Khine M","Si Z","Lin L","Chang X","Xia F"],"additional_accession":[]},"is_claimable":false,"name":"A wrinkled structure of gold film greatly improves the signaling of electrochemical aptamer-based biosensors.","description":"Electrochemical aptamer-based (E-AB) sensors provide a great opportunity towards the goal of point-of-care and wearable sensing technologies due to their good sensitivity and selectivity. Nevertheless, the output signals from this sensor class remain low when sensors are interrogated <i>via</i> square-wave voltammetry. This low signaling limits the sensor's precision for its capability to detect small changes in target concentrations. To circumvent this, we proposed here the use of a readily shrink-induced, wrinkled Au-coating polyolefin film to immobilize a greater number of DNA probes and thus improve the signaling. Specifically, wrinkled gold film exhibits a 5.5-fold increase of surface area in comparison to the unwrinkled ones. Using these substrates we fabricated a set of E-AB sensors","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-25T22:21:41.93Z","creation":"2025-04-06T09:05:10.773Z"},"accession":"S-EPMC8693351","cross_references":{"pubmed":["35423693"],"doi":["10.1039/d0ra09174j"]}}