{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zuniga A"],"funding":["NIAAA NIH HHS"],"pagination":["108795"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694014"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["200"],"pubmed_abstract":["Previous studies in rodents have repeatedly demonstrated that the centrally-projecting Edinger-Westphal nucleus (EWcp) is highly sensitive to alcohol and is also involved in regulating alcohol intake and body temperature. Historically, the EWcp has been known as the main site of Urocortin 1 (Ucn1) expression, a corticotropin-releasing factor-related peptide, in the brain. However, the EWcp also contains other populations of neurons, including neurons that express the vesicular glutamate transporter 2 (Vglut2). Here we transduced the EWcp with adeno-associated viruses (AAVs) encoding Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to test the role of the EWcp in alcohol drinking and in the regulation of body temperature. Activation of the EWcp with excitatory DREADDs in"],"journal":["Neuropharmacology"],"pubmed_title":["Vesicular glutamate transporter 2-containing neurons of the centrally-projecting Edinger-Westphal nucleus regulate alcohol drinking and body temperature."],"pmcid":["PMC8694014"],"funding_grant_id":["R01 AA007702","R01 AA025024","T32 AA007468","F31 AA022824","R01 AA019793"],"pubmed_authors":["Caruso M","Smith ML","Ryabinin AE","Zuniga A"],"additional_accession":[]},"is_claimable":false,"name":"Vesicular glutamate transporter 2-containing neurons of the centrally-projecting Edinger-Westphal nucleus regulate alcohol drinking and body temperature.","description":"Previous studies in rodents have repeatedly demonstrated that the centrally-projecting Edinger-Westphal nucleus (EWcp) is highly sensitive to alcohol and is also involved in regulating alcohol intake and body temperature. Historically, the EWcp has been known as the main site of Urocortin 1 (Ucn1) expression, a corticotropin-releasing factor-related peptide, in the brain. However, the EWcp also contains other populations of neurons, including neurons that express the vesicular glutamate transporter 2 (Vglut2). Here we transduced the EWcp with adeno-associated viruses (AAVs) encoding Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to test the role of the EWcp in alcohol drinking and in the regulation of body temperature. Activation of the EWcp with excitatory DREADDs in","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T09:43:12.139Z","creation":"2025-04-05T09:43:12.139Z"},"accession":"S-EPMC8694014","cross_references":{"pubmed":["34555367"],"doi":["10.1016/j.neuropharm.2021.108795"]}}