{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Narr K"],"funding":["Swiss National Science Foundation","European Research Council","Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung"],"pagination":["e2108157118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694065"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(46)"],"pubmed_abstract":["Chronic viral infections subvert protective B cell immunity. An early type I interferon (IFN-I)-driven bias to short-lived plasmablast differentiation leads to clonal deletion, so-called \"decimation,\" of antiviral memory B cells. Therefore, prophylactic countermeasures against decimation remain an unmet need. We show that vaccination-induced CD4 T cells prevented the decimation of naïve and memory B cells in chronically lymphocytic choriomeningitis virus (LCMV)-infected mice. Although these B cell responses were largely T independent when IFN-I was blocked, preexisting T help assured their sustainability under conditions of IFN-I-driven inflammation by instructing a germinal center B cell transcriptional program. Prevention of decimation depended on T cell-intrinsic Bcl6 and Tfh progeny fo"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection."],"pmcid":["PMC8694065"],"funding_grant_id":["323630","323630_151472","310962","310030","151472","173010","310030_173010","310030_173132","173132"],"pubmed_authors":["Ertuna YI","Dimitrova M","Wagner I","Cornille K","Abreu Mota T","Merkler D","Marx AF","Lohning M","Kunzli M","King CG","Pinschewer DD","Martin K","Geier F","Fallet B","Bestmann L","Narr K","Kreutzfeldt M","Schreiner D","Brunner TM"],"additional_accession":[]},"is_claimable":false,"name":"Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection.","description":"Chronic viral infections subvert protective B cell immunity. An early type I interferon (IFN-I)-driven bias to short-lived plasmablast differentiation leads to clonal deletion, so-called \"decimation,\" of antiviral memory B cells. Therefore, prophylactic countermeasures against decimation remain an unmet need. We show that vaccination-induced CD4 T cells prevented the decimation of naïve and memory B cells in chronically lymphocytic choriomeningitis virus (LCMV)-infected mice. Although these B cell responses were largely T independent when IFN-I was blocked, preexisting T help assured their sustainability under conditions of IFN-I-driven inflammation by instructing a germinal center B cell transcriptional program. Prevention of decimation depended on T cell-intrinsic Bcl6 and Tfh progeny fo","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T07:46:36.552Z","creation":"2025-04-04T07:46:36.552Z"},"accession":"S-EPMC8694065","cross_references":{"pubmed":["34772811"],"doi":["10.1073/pnas.2108157118"]}}