{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hara T"],"funding":["MEXT | Japan Society for the Promotion of Science","Kyoto University | Institute of Advanced Energy, Kyoto University"],"pagination":["e0192621"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694117"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Polychlorinated biphenyls (PCBs) are recalcitrant organohalide pollutants, consisting of 209 congeners. PCB cleanup in natural landscapes is expected to be achieved by the metabolic activity of microorganisms, but aerobic PCB-degrading bacteria that inhabit sites polluted by PCBs cannot degrade all PCB congeners due to the specificity of their enzymes. In this study, we investigated the degradability of PCBs when a genetically modified PCB-degrading bacterium was compounded with wild-type PCB-degrading bacteria. We used two bacterial strains, Comamonas testosteroni YAZ2 isolated from a PCB-uncontaminated natural landscape and Escherichia coli BL21(DE3) transformed with a biphenyl dioxygenase (BphA) gene from a well-known PCB degrader, Burkholderia xenovorans LB400. The enzymatic specificit"],"journal":["Microbiology spectrum"],"pubmed_title":["Augmentation of an Engineered Bacterial Strain Potentially Improves the Cleanup of PCB Water Pollution."],"pmcid":["PMC8694117"],"funding_grant_id":["JP26550066","ZE28C-11","ZE29A-10","JP18K19881"],"pubmed_authors":["Nakata E","Hara T","Morii T","Takatsuka Y"],"additional_accession":[]},"is_claimable":false,"name":"Augmentation of an Engineered Bacterial Strain Potentially Improves the Cleanup of PCB Water Pollution.","description":"Polychlorinated biphenyls (PCBs) are recalcitrant organohalide pollutants, consisting of 209 congeners. PCB cleanup in natural landscapes is expected to be achieved by the metabolic activity of microorganisms, but aerobic PCB-degrading bacteria that inhabit sites polluted by PCBs cannot degrade all PCB congeners due to the specificity of their enzymes. In this study, we investigated the degradability of PCBs when a genetically modified PCB-degrading bacterium was compounded with wild-type PCB-degrading bacteria. We used two bacterial strains, Comamonas testosteroni YAZ2 isolated from a PCB-uncontaminated natural landscape and Escherichia coli BL21(DE3) transformed with a biphenyl dioxygenase (BphA) gene from a well-known PCB degrader, Burkholderia xenovorans LB400. The enzymatic specificit","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-05-18T12:04:14.554Z","creation":"2025-04-05T20:39:58.076Z"},"accession":"S-EPMC8694117","cross_references":{"pubmed":["34937186"],"doi":["10.1128/spectrum.01926-21"]}}