biostudies-literatureLu SOffice of Experimental Program to Stimulate Competitive ResearchNational Institute of Food and Agriculture4472-4477https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694451biostudies-literatureUnknown11(8)2D nickel phthalocyanine based MOFs (NiPc-MOFs) with excellent conductivity were synthesized through a solvothermal approach. Benefiting from excellent conductivity and a large surface area, 2D NiPc-MOF nanosheets present excellent electrocatalytic activity for nitrite sensing, with an ultra-wide linear concentration from 0.01 mM to 11 500 mM and a low detection limit of 2.3 μM, better than most reported electrochemical nitrite sensors. Significantly, this work reports the synthesis of 2D conductive NiPc-MOFs and develops them as electrochemical biosensors for non-enzymatic nitrite determination for the first time.RSC advancesTwo-dimensional conductive phthalocyanine-based metal-organic frameworks for electrochemical nitrite sensing.PMC8694451SD00H618-16OIA-1849206SD00R680-19 NC1194Qi XLu SJia HGu ZHummel MWu YWang KfalseTwo-dimensional conductive phthalocyanine-based metal-organic frameworks for electrochemical nitrite sensing.2D nickel phthalocyanine based MOFs (NiPc-MOFs) with excellent conductivity were synthesized through a solvothermal approach. Benefiting from excellent conductivity and a large surface area, 2D NiPc-MOF nanosheets present excellent electrocatalytic activity for nitrite sensing, with an ultra-wide linear concentration from 0.01 mM to 11 500 mM and a low detection limit of 2.3 μM, better than most reported electrochemical nitrite sensors. Significantly, this work reports the synthesis of 2D conductive NiPc-MOFs and develops them as electrochemical biosensors for non-enzymatic nitrite determination for the first time.2021-01-01T00:00:00Z2021 Jan2025-04-22T10:00:15.732Z2025-04-05T23:21:58.116ZS-EPMC86944513542439410.1039/d0ra10522h