biostudies-literatureUnknown11(8)Xing WLA transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and α-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C-Se bonds under the simple and mild reaction conditions. Moreover, the protocol is successfully applied to the late-stage modification of pharmaceutical carboxylates with satisfactory chemoselectivity and functional-group compatibility.RSC advances4593-4597https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694499biostudies-literatureTransition-metal-free decarboxylative thiolation of stable aliphatic carboxylates.PMC8694499Xing WLLiu DGFu MCfalseTransition-metal-free decarboxylative thiolation of stable aliphatic carboxylates.A transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and α-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C-Se bonds under the simple and mild reaction conditions. Moreover, the protocol is successfully applied to the late-stage modification of pharmaceutical carboxylates with satisfactory chemoselectivity and functional-group compatibility.2021-01-01T00:00:00Z2021 Jan2025-04-22T22:04:12.083Z2025-04-06T03:55:18.376ZS-EPMC86944993542441710.1039/d1ra00063b