{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng L"],"funding":["National Natural Science Foundation of China"],"pagination":["5080-5085"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694552"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(9)"],"pubmed_abstract":["Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I<sub>2</sub> and KH<sub>2</sub>PO<sub>2</sub>, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)<sub>3</sub>, esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I<sub>2</sub>/KH<sub>2</sub>PO<sub>2</sub> protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed."],"journal":["RSC advances"],"pubmed_title":["Mechanically induced solvent-free esterification method at room temperature."],"pmcid":["PMC8694552"],"funding_grant_id":["21978270"],"pubmed_authors":["Dushkin AV","Polyakov N","Zheng L","Sun C","Yu J","Xu W","Su W"],"additional_accession":[]},"is_claimable":false,"name":"Mechanically induced solvent-free esterification method at room temperature.","description":"Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I<sub>2</sub> and KH<sub>2</sub>PO<sub>2</sub>, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)<sub>3</sub>, esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I<sub>2</sub>/KH<sub>2</sub>PO<sub>2</sub> protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-04T19:57:59.608Z","creation":"2025-04-04T19:57:59.608Z"},"accession":"S-EPMC8694552","cross_references":{"pubmed":["35424454"],"doi":["10.1039/d0ra09437d"]}}