biostudies-literatureNguyen TTNational Foundation for Science and Technology Development5451-5455https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694682biostudies-literatureUnknown11(10)We report a method for addition of α-bromophenylacetic acids to vinyl C[double bond, length as m-dash]C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO₃)₂·6H₂O in the presence of dipivaloylmethane (dpm) ligand. Many functionalities including halogen, ester, and nitro groups were compatible with reaction conditions. If α-bromoesters were used, vinylacetates were the major products.RSC advancesCobalt-catalyzed annulation of styrenes with α-bromoacetic acids.PMC8694682104.01-2019.44Ngo BHTTo TAPhan ANQNguyen TTPhan NTSLe HXVu LNPfalseCobalt-catalyzed annulation of styrenes with α-bromoacetic acids.We report a method for addition of α-bromophenylacetic acids to vinyl C[double bond, length as m-dash]C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO₃)₂·6H₂O in the presence of dipivaloylmethane (dpm) ligand. Many functionalities including halogen, ester, and nitro groups were compatible with reaction conditions. If α-bromoesters were used, vinylacetates were the major products.2021-01-01T00:00:00Z2021 Jan2025-04-22T09:58:15.86Z2025-04-05T23:21:24.33ZS-EPMC86946823542309210.1039/d0ra09588e