{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Umehara Y"],"funding":["Universität Wien","Japan Society for the Promotion of Science"],"pagination":["5865-5873"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694775"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["Molecular oxygen plays an important role in living organisms. Its concentration and fluctuation in cells or tissues are related to many diseases. Therefore, there is a need for molecular systems that can be used to detect and quantify oxygen levels <i>in vitro</i> and <i>in vivo</i>. In this study, we synthesized phosphonated mesoporous silica nanoparticles bearing ruthenium complexes in their pores (pM-Rus) and evaluated their photophysical and biological properties. The pM-Rus were highly soluble in water and showed robust phosphorescence under hypoxic conditions, while the addition of oxygen suppressed this emission. Cellular experiments revealed that pM-Rus with a size of 100 nm showed efficient cellular uptake to emit phosphorescence in hypoxic cells. In addition, pM-Rus have negligib"],"journal":["RSC advances"],"pubmed_title":["Phosphonated mesoporous silica nanoparticles bearing ruthenium complexes used as molecular probes for tracking oxygen levels in cells and tissues."],"pmcid":["PMC8694775"],"funding_grant_id":["17J03866"],"pubmed_authors":["Kleitz F","Kimura Y","Kondo T","Tanabe K","Umehara Y","Nishihara T"],"additional_accession":[]},"is_claimable":false,"name":"Phosphonated mesoporous silica nanoparticles bearing ruthenium complexes used as molecular probes for tracking oxygen levels in cells and tissues.","description":"Molecular oxygen plays an important role in living organisms. Its concentration and fluctuation in cells or tissues are related to many diseases. Therefore, there is a need for molecular systems that can be used to detect and quantify oxygen levels <i>in vitro</i> and <i>in vivo</i>. In this study, we synthesized phosphonated mesoporous silica nanoparticles bearing ruthenium complexes in their pores (pM-Rus) and evaluated their photophysical and biological properties. The pM-Rus were highly soluble in water and showed robust phosphorescence under hypoxic conditions, while the addition of oxygen suppressed this emission. Cellular experiments revealed that pM-Rus with a size of 100 nm showed efficient cellular uptake to emit phosphorescence in hypoxic cells. In addition, pM-Rus have negligib","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-05-31T23:34:40.569Z","creation":"2025-05-31T23:34:40.569Z"},"accession":"S-EPMC8694775","cross_references":{"pubmed":["35423078"],"doi":["10.1039/d0ra08771h"]}}