biostudies-literatureUnknown11(11)Horst FHUniversidade de BrasíliaFundação de Apoio à Pesquisa do Distrito FederalConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorLaboratório Nacional de Luz SíncrotronBioactive carbon dots (C-dots) with <i>ca.</i> 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the "light-up" behaviour enabled them to be explored in glucose detection and bioimaging experiments (mitochondrial selective probe). C-dots were not selective to the tumour region and several fluorescent spots were visualized spread on animal bodies. The histology investigations showed that cancer-bearing mice treated with C-dots presented a large number of regions with necrosis and inflammatory infiltrates, which were not identified for cancer-bearing mice without the treatment. These results suggested that C-dots have the potential to be explored as an immune RSC advances6346-6352https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694864biostudies-literatureFrom cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer.PMC8694864Rodrigues CVDSCarvalho PHPRCorrea JRLeite AMGarcia MPAlotaibi SChaves SBNeto BADHenini MRodrigues MOHorst FHAzevedo RBfalseFrom cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer.Bioactive carbon dots (C-dots) with <i>ca.</i> 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the "light-up" behaviour enabled them to be explored in glucose detection and bioimaging experiments (mitochondrial selective probe). C-dots were not selective to the tumour region and several fluorescent spots were visualized spread on animal bodies. The histology investigations showed that cancer-bearing mice treated with C-dots presented a large number of regions with necrosis and inflammatory infiltrates, which were not identified for cancer-bearing mice without the treatment. These results suggested that C-dots have the potential to be explored as an immune 2021-01-01T00:00:00Z2021 Feb2025-04-25T23:01:06.172Z2025-04-06T09:13:36.105ZS-EPMC86948643542315610.1039/d0ra10859f