{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Du Y"],"funding":["National Natural Science Foundation of China"],"pagination":["6472-6476"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694898"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(12)"],"pubmed_abstract":["New nano-reagents with diagnostic imaging and therapeutic functions are very important for precision medicine against cancer. In this work, a new nanotheraontic agent for magnetic resonance imaging (MRI) guided combined photothermal therapy (PTT) and chemotherapy was constructed based on polydopamine (PDA) functionalized copper ferrite nanospheres (PDA@CFNs). The high relaxivity makes it possible for PDA@CFNs to become a promising MRI contrast agent, providing necessary and exhaustive information for tumor diagnosis. In addition, because both CFNs and PDA have strong near-infrared (NIR) absorption, PDA@CFNs exhibit excellent photothermal performance. Highly effective tumor ablation is achieved in a mouse model through PTT and pH/NIR triggered on-demand chemotherapy. These findings reveal t"],"journal":["RSC advances"],"pubmed_title":["A new pH/NIR responsive theranostic agent for magnetic resonance imaging guided synergistic therapy."],"pmcid":["PMC8694898"],"funding_grant_id":["52072142"],"pubmed_authors":["Li W","Wang S","Wang D","Du Y","Suo J"],"additional_accession":[]},"is_claimable":false,"name":"A new pH/NIR responsive theranostic agent for magnetic resonance imaging guided synergistic therapy.","description":"New nano-reagents with diagnostic imaging and therapeutic functions are very important for precision medicine against cancer. In this work, a new nanotheraontic agent for magnetic resonance imaging (MRI) guided combined photothermal therapy (PTT) and chemotherapy was constructed based on polydopamine (PDA) functionalized copper ferrite nanospheres (PDA@CFNs). The high relaxivity makes it possible for PDA@CFNs to become a promising MRI contrast agent, providing necessary and exhaustive information for tumor diagnosis. In addition, because both CFNs and PDA have strong near-infrared (NIR) absorption, PDA@CFNs exhibit excellent photothermal performance. Highly effective tumor ablation is achieved in a mouse model through PTT and pH/NIR triggered on-demand chemotherapy. These findings reveal t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-25T23:01:53.449Z","creation":"2025-04-06T09:13:52.884Z"},"accession":"S-EPMC8694898","cross_references":{"pubmed":["35423169"],"doi":["10.1039/d0ra09538a"]}}