biostudies-literatureDu YNational Natural Science Foundation of China6472-6476https://www.ebi.ac.uk/biostudies/studies/S-EPMC8694898biostudies-literatureUnknown11(12)New nano-reagents with diagnostic imaging and therapeutic functions are very important for precision medicine against cancer. In this work, a new nanotheraontic agent for magnetic resonance imaging (MRI) guided combined photothermal therapy (PTT) and chemotherapy was constructed based on polydopamine (PDA) functionalized copper ferrite nanospheres (PDA@CFNs). The high relaxivity makes it possible for PDA@CFNs to become a promising MRI contrast agent, providing necessary and exhaustive information for tumor diagnosis. In addition, because both CFNs and PDA have strong near-infrared (NIR) absorption, PDA@CFNs exhibit excellent photothermal performance. Highly effective tumor ablation is achieved in a mouse model through PTT and pH/NIR triggered on-demand chemotherapy. These findings reveal tRSC advancesA new pH/NIR responsive theranostic agent for magnetic resonance imaging guided synergistic therapy.PMC869489852072142Li WWang SWang DDu YSuo JfalseA new pH/NIR responsive theranostic agent for magnetic resonance imaging guided synergistic therapy.New nano-reagents with diagnostic imaging and therapeutic functions are very important for precision medicine against cancer. In this work, a new nanotheraontic agent for magnetic resonance imaging (MRI) guided combined photothermal therapy (PTT) and chemotherapy was constructed based on polydopamine (PDA) functionalized copper ferrite nanospheres (PDA@CFNs). The high relaxivity makes it possible for PDA@CFNs to become a promising MRI contrast agent, providing necessary and exhaustive information for tumor diagnosis. In addition, because both CFNs and PDA have strong near-infrared (NIR) absorption, PDA@CFNs exhibit excellent photothermal performance. Highly effective tumor ablation is achieved in a mouse model through PTT and pH/NIR triggered on-demand chemotherapy. These findings reveal t2021-01-01T00:00:00Z2021 Feb2025-04-25T23:01:53.449Z2025-04-06T09:13:52.884ZS-EPMC86948983542316910.1039/d0ra09538a