{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(24)"],"submitter":["Lee F"],"funding":["Agency for Science, Technology and Research"],"pubmed_abstract":["Fibroblast-like synoviocytes are a key effector cell type involved in the pathogenesis of rheumatoid arthritis. The major green tea catechin, epigallocatechin-3-<i>O</i>-gallate (EGCG), has attracted significant interest for rheumatoid arthritis therapy because of its ability to suppress the proliferation and interleukin-6 secretion of synoviocytes. However, therapeutic efficacy of EGCG has been limited by a lack of target cell specificity. Herein we report hyaluronic acid-EGCG (HA-EGCG) conjugates as an anti-arthritic agent that is capable of targeting fibroblast-like synoviocytes <i>via</i> HA-CD44 interactions. These conjugates exhibited superior anti-proliferative and anti-inflammatory activities compared with EGCG under simulated physiological conditions. Near-infrared fluorescence imaging revealed preferential accumulation of the conjugates at inflamed joints in a collagen-induced arthritis rat model, and their anti-arthritic efficacy was investigated by measuring a change in the edema and histopathological scores. Our findings suggest the potential of HA-EGCG conjugates as an anti-arthritic agent for the treatment of rheumatoid arthritis."],"journal":["RSC advances"],"pagination":["14285-14294"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8697692"],"repository":["biostudies-literature"],"pubmed_title":["Hyaluronic acid-green tea catechin conjugates as a potential therapeutic agent for rheumatoid arthritis."],"pmcid":["PMC8697692"],"pubmed_authors":["Bae KH","Ng S","Yamashita A","Lee F","Kurisawa M"],"additional_accession":[]},"is_claimable":false,"name":"Hyaluronic acid-green tea catechin conjugates as a potential therapeutic agent for rheumatoid arthritis.","description":"Fibroblast-like synoviocytes are a key effector cell type involved in the pathogenesis of rheumatoid arthritis. The major green tea catechin, epigallocatechin-3-<i>O</i>-gallate (EGCG), has attracted significant interest for rheumatoid arthritis therapy because of its ability to suppress the proliferation and interleukin-6 secretion of synoviocytes. However, therapeutic efficacy of EGCG has been limited by a lack of target cell specificity. Herein we report hyaluronic acid-EGCG (HA-EGCG) conjugates as an anti-arthritic agent that is capable of targeting fibroblast-like synoviocytes <i>via</i> HA-CD44 interactions. These conjugates exhibited superior anti-proliferative and anti-inflammatory activities compared with EGCG under simulated physiological conditions. Near-infrared fluorescence imaging revealed preferential accumulation of the conjugates at inflamed joints in a collagen-induced arthritis rat model, and their anti-arthritic efficacy was investigated by measuring a change in the edema and histopathological scores. Our findings suggest the potential of HA-EGCG conjugates as an anti-arthritic agent for the treatment of rheumatoid arthritis.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-05T13:07:59.54Z","creation":"2025-04-05T13:07:59.54Z"},"accession":"S-EPMC8697692","cross_references":{"pubmed":["35423998"],"doi":["10.1039/d1ra01491a"]}}