biostudies-literatureUnknown11(12)Yang LThis study aimed to find the SNPs in the <i>SORBS</i>1 gene of cattleyak, analyze the relationship between its polymorphisms and the milk fat traits, and find potential molecular markers for the milk fat traits of cattleyak. The polymorphism of the <i>SORBS</i>1 gene in 350 cattleyak from Hongyuan County (Sichuan, China) were detected by PCR and DNA sequencing, and the correlation between these SNPs and the milk production traits of cattleyak was analyzed. The results showed that there were nine SNPs in the CDS and their adjacent non-coding regions of the <i>SORBS</i>1 gene, and all SNPs have three genotypes. The correlation analysis found that the genotypes with superior milk fat traits in the other eight alleles were homozygous genotypes with a high genotype frequency except the g.96284 Animals : an open access journal from MDPI3461https://www.ebi.ac.uk/biostudies/studies/S-EPMC8697865biostudies-literaturePolymorphisms of <i>SORBS</i>1 Gene and Their Correlation with Milk Fat Traits of Cattleyak.PMC8697865Li JYang LMin XHu YZhu YYang MYu HXiong XfalsePolymorphisms of <i>SORBS</i>1 Gene and Their Correlation with Milk Fat Traits of Cattleyak.This study aimed to find the SNPs in the <i>SORBS</i>1 gene of cattleyak, analyze the relationship between its polymorphisms and the milk fat traits, and find potential molecular markers for the milk fat traits of cattleyak. The polymorphism of the <i>SORBS</i>1 gene in 350 cattleyak from Hongyuan County (Sichuan, China) were detected by PCR and DNA sequencing, and the correlation between these SNPs and the milk production traits of cattleyak was analyzed. The results showed that there were nine SNPs in the CDS and their adjacent non-coding regions of the <i>SORBS</i>1 gene, and all SNPs have three genotypes. The correlation analysis found that the genotypes with superior milk fat traits in the other eight alleles were homozygous genotypes with a high genotype frequency except the g.96284 2021-01-01T00:00:00Z2021 Dec2026-04-08T07:08:07.253Z2022-02-11T14:36:58.134ZS-EPMC86978653494423910.3390/ani11123461