{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Xu B"],"pubmed_abstract":["A novel copper-catalyzed thioetherification reaction has been developed to afford benzyl thioethers in moderate to excellent yields. Under the mild and easy-to-operate conditions, a variety of thioethers are efficiently prepared from readily available benzyl alcohols (primary, secondary, and tertiary) and thiols in the presence of Cu(OTf)<sub>2</sub> as the Lewis acid catalysis. This C-S bond formation protocol furnishes exceptional chemoselectivity, and the preliminary mechanism studies show that the reaction should proceed through a Lewis-acid-mediated S<sub>N</sub>1-type nucleophilic attack of the carbocations formed <i>in situ</i>."],"journal":["RSC advances"],"pagination":["692-697"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8697992"],"repository":["biostudies-literature"],"pubmed_title":["Benzyl thioether formation merging copper catalysis."],"pmcid":["PMC8697992"],"pubmed_authors":["Xu L","Xie T","Ye XY","Xu B","Lin Y","Ye Y"],"additional_accession":[]},"is_claimable":false,"name":"Benzyl thioether formation merging copper catalysis.","description":"A novel copper-catalyzed thioetherification reaction has been developed to afford benzyl thioethers in moderate to excellent yields. Under the mild and easy-to-operate conditions, a variety of thioethers are efficiently prepared from readily available benzyl alcohols (primary, secondary, and tertiary) and thiols in the presence of Cu(OTf)<sub>2</sub> as the Lewis acid catalysis. This C-S bond formation protocol furnishes exceptional chemoselectivity, and the preliminary mechanism studies show that the reaction should proceed through a Lewis-acid-mediated S<sub>N</sub>1-type nucleophilic attack of the carbocations formed <i>in situ</i>.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T09:00:29.972Z","creation":"2025-04-04T09:00:29.972Z"},"accession":"S-EPMC8697992","cross_references":{"pubmed":["35425124"],"doi":["10.1039/d1ra08015f"]}}