biostudies-literatureAkhavan MNational Institute for Medical Research DevelopmentMazandaran University of Medical Sciences14755-14768https://www.ebi.ac.uk/biostudies/studies/S-EPMC8698206biostudies-literatureUnknown11(24)An efficient, green, one-pot, and three-component protocol has been reported for the stereoselective synthesis of a new class of spiro thiazolidines. A series of spiro-heterocycle derivatives were produced stereoselectively in high yields by the reaction of 5-arylidene thiazolidine-2,4-diones, isatin, and secondary amino acids in the presence of MnCoCuFe₂O₄@l-proline (MCCFe₂O₄@l-proline) magnetic nanorods as a novel nanocatalyst. The synthesized catalyst was fully characterized for thermal stability, magnetic properties, and other physicochemical properties <i>via</i> numerous techniques. It was applied as an efficient and reusable catalyst for the synthesis of <i>endo</i>-isomers of spirocyclic pyrrolidine/pyrrolizidine/pyrrolothiazolidine derivRSC advancesStereoselective synthesis of spirocyclic pyrrolidines/pyrrolizidines/pyrrolothiazolidines using l-proline functionalized manganese ferrite nanorods as a novel heterogeneous catalyst.PMC8698206971338Akhavan MBekhradnia AfalseStereoselective synthesis of spirocyclic pyrrolidines/pyrrolizidines/pyrrolothiazolidines using l-proline functionalized manganese ferrite nanorods as a novel heterogeneous catalyst.An efficient, green, one-pot, and three-component protocol has been reported for the stereoselective synthesis of a new class of spiro thiazolidines. A series of spiro-heterocycle derivatives were produced stereoselectively in high yields by the reaction of 5-arylidene thiazolidine-2,4-diones, isatin, and secondary amino acids in the presence of MnCoCuFe₂O₄@l-proline (MCCFe₂O₄@l-proline) magnetic nanorods as a novel nanocatalyst. The synthesized catalyst was fully characterized for thermal stability, magnetic properties, and other physicochemical properties <i>via</i> numerous techniques. It was applied as an efficient and reusable catalyst for the synthesis of <i>endo</i>-isomers of spirocyclic pyrrolidine/pyrrolizidine/pyrrolothiazolidine deriv2021-01-01T00:00:00Z2021 Apr2025-04-04T19:58:02.38Z2025-04-04T19:58:02.38ZS-EPMC86982063542397310.1039/d1ra00841b