{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chung GE"],"funding":["Liver Research Foundation of Korea","Seoul National University Hospital"],"pagination":["1948"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8698513"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(12)"],"pubmed_abstract":["Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in MetS and subsequent nonviral LC development. Data were obtained from the Korean National Health Insurance Service. Individuals who participated in health screenings from both 2009 to 2010 and 2011 to 2012 were included. The primary outcome was LC development according to the static and dynamic MetS status. Subjects were stratified into four groups according to the change in MetS status observed from the two-year interval screening (2009-2011). Cox regression analysis was used to examine the hazard ratios of"],"journal":["Biomedicines"],"pubmed_title":["The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis."],"pmcid":["PMC8698513"],"funding_grant_id":["Bio Future Strategies Research Project","06-2020-4150"],"pubmed_authors":["Yu SJ","Cho Y","Han K","Kim YJ","Yoo JJ","Cho EJ","Yoon JH","Park SH","Chang Y","Chung GE","Shin DW"],"additional_accession":[]},"is_claimable":false,"name":"The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis.","description":"Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in MetS and subsequent nonviral LC development. Data were obtained from the Korean National Health Insurance Service. Individuals who participated in health screenings from both 2009 to 2010 and 2011 to 2012 were included. The primary outcome was LC development according to the static and dynamic MetS status. Subjects were stratified into four groups according to the change in MetS status observed from the two-year interval screening (2009-2011). Cox regression analysis was used to examine the hazard ratios of","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-06-01T02:56:16.187Z","creation":"2025-06-01T02:56:16.187Z"},"accession":"S-EPMC8698513","cross_references":{"pubmed":["34944764"],"doi":["10.3390/biomedicines9121948"]}}