{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Rojas I"],"funding":["Grifols SA, Fundación bancaria ‘La Caixa’, Fundació ACE, and CIBERNED","Grifols SA, Fundación bancaria 'La Caixa', Fundació ACE, and CIBERNED","Queen Sofia Foundation and the Instituto de Salud Carlos III","Medical Research Council"],"pagination":["1318"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8708271"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(12)"],"pubmed_abstract":["Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the <i>APOE</i> locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (<i>LZTFL"],"journal":["Journal of personalized medicine"],"pubmed_title":["Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study."],"pmcid":["PMC8708271"],"funding_grant_id":["NA","MR/K010395/1"],"pubmed_authors":["Rosas Allende I","Real LM","Orellana A","Mendoza S","Mir P","Menendez-Gonzalez M","Pinol-Ripoll G","Franco-Macias E","Hernandez I","Pineda JA","Butler CR","Calero M","Puerta R","Bernal Sanchez-Arjona M","Buiza-Rueda D","Lage C","Alonso-Lana S","Martin Montes A","Tarraga L","Carracedo A","Macias J","Garcia-Ribas G","Gr Ace/Degesco Consortium","Boada M","Gonzalez-Perez A","Garcia-Alberca JM","Perinan MT","Huerto Vilas R","Saez ME","Marquie M","Bullido MJ","Royo JL","Arias Pastor A","Corma-Gomez A","Sanchez-Juan P","Martinez Rodriguez C","Rabano A","Fernandez-Fuertes M","Sotolongo-Grau O","Alvarez V","Alvarez I","Aguilera N","Garcia-Gonzalez P","Montrreal L","Garcia-Madrona S","de Rojas I","Pastor P","Pastor AB","Rodriguez-Rodriguez E","Medina M","Diez-Fairen M","Frank-Garcia A","Quintela I","Ruiz A","Del Ser T"],"additional_accession":[]},"is_claimable":false,"name":"Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study.","description":"Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the <i>APOE</i> locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (<i>LZTFL","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-04-08T06:49:57.732Z","creation":"2022-02-11T14:42:43.541Z"},"accession":"S-EPMC8708271","cross_references":{"pubmed":["34945790"],"doi":["10.3390/jpm11121318"]}}