biostudies-literaturede Rojas IGrifols SA, Fundación bancaria ‘La Caixa’, Fundació ACE, and CIBERNEDGrifols SA, Fundación bancaria 'La Caixa', Fundació ACE, and CIBERNEDQueen Sofia Foundation and the Instituto de Salud Carlos IIIMedical Research Council1318https://www.ebi.ac.uk/biostudies/studies/S-EPMC8708271biostudies-literatureUnknown11(12)Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the <i>APOE</i> locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (<i>LZTFLJournal of personalized medicineGenomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study.PMC8708271NAMR/K010395/1Rosas Allende IReal LMOrellana AMendoza SMir PMenendez-Gonzalez MPinol-Ripoll GFranco-Macias EHernandez IPineda JAButler CRCalero MPuerta RBernal Sanchez-Arjona MBuiza-Rueda DLage CAlonso-Lana SMartin Montes ATarraga LCarracedo AMacias JGarcia-Ribas GGr Ace/Degesco ConsortiumBoada MGonzalez-Perez AGarcia-Alberca JMPerinan MTHuerto Vilas RSaez MEMarquie MBullido MJRoyo JLArias Pastor ACorma-Gomez ASanchez-Juan PMartinez Rodriguez CRabano AFernandez-Fuertes MSotolongo-Grau OAlvarez VAlvarez IAguilera NGarcia-Gonzalez PMontrreal LGarcia-Madrona Sde Rojas IPastor PPastor ABRodriguez-Rodriguez EMedina MDiez-Fairen MFrank-Garcia AQuintela IRuiz ADel Ser TfalseGenomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study.Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the <i>APOE</i> locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (<i>LZTFL2021-01-01T00:00:00Z2021 Dec2026-04-08T06:49:57.732Z2022-02-11T14:42:43.541ZS-EPMC87082713494579010.3390/jpm11121318