{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(12)"],"submitter":["Ramage KS"],"pubmed_abstract":["High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for the parasitic nematode Haemonchus contortus identified an active extract derived from the Australian marine sponge Citronia sp. Bioassay-guided fractionation of the CH2Cl2/MeOH extract from Citronia sp. resulted in the purification of two known hexachlorinated peptides, dysidenin (1) and dysideathiazole (2). Compound 1 inhibited the growth/development of H. contortus larvae and induced multiple phenotypic changes, including a lethal evisceration (Evi) phenotype and/or somatic cell and tissue destruction. This is the first report of anthelmintic activity for these rare and unique polychlorinated peptides."],"journal":["Marine drugs"],"pagination":["698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8708643"],"repository":["biostudies-literature"],"pubmed_title":["Dysidenin from the Marine Sponge Citronia sp. Affects the Motility and Morphology of Haemonchus contortus Larvae In Vitro."],"pmcid":["PMC8708643"],"pubmed_authors":["Taki AC","Ramage KS","Gasser RB","White JM","Wang T","Jabbar A","Davis RA","Lum KY","Ekins MG","Byrne JJ","Hofmann A","Hayes S"],"additional_accession":[]},"is_claimable":false,"name":"Dysidenin from the Marine Sponge Citronia sp. Affects the Motility and Morphology of Haemonchus contortus Larvae In Vitro.","description":"High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for the parasitic nematode Haemonchus contortus identified an active extract derived from the Australian marine sponge Citronia sp. Bioassay-guided fractionation of the CH2Cl2/MeOH extract from Citronia sp. resulted in the purification of two known hexachlorinated peptides, dysidenin (1) and dysideathiazole (2). Compound 1 inhibited the growth/development of H. contortus larvae and induced multiple phenotypic changes, including a lethal evisceration (Evi) phenotype and/or somatic cell and tissue destruction. This is the first report of anthelmintic activity for these rare and unique polychlorinated peptides.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2024-02-15T22:19:04.323Z","creation":"2022-02-11T14:04:45.039Z"},"accession":"S-EPMC8708643","cross_references":{"pubmed":["34940697"],"doi":["10.3390/md19120698"]}}