{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schwartzman JM"],"funding":["NCATS NIH HHS","NICHD NIH HHS","national center for advancing translational sciences","NIMH NIH HHS","National Institute of Mental Health","NIGMS NIH HHS"],"pagination":["256-269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8710183"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Lay abstract</h4>Depression is more common in autistic adolescents than their neurotypical peers, but the effects of diagnosis and sex on the severity and types of depressive symptoms remain unclear. The study explored diagnostic- and sex-based differences in depressive symptoms in 212 autistic and neurotypical early adolescents. Results show that autism spectrum disorder and female may pose elevated risks, and depressive symptoms related to interpersonal problems and negative self-esteem are more frequent in autism spectrum disorder. Autistic males and females endorsed similar severity and type of depressive symptoms, but unique differences emerged when compared to sex-matched neurotypical peers. Exploratory analyses in a clinical subsample of early adolescents with elevated depressive symptoms (Children's Depression Inventory, Second Edition, Total <i>T</i>-score ⩾60) revealed more endorsement of beliefs of worthlessness in autistic early adolescents. Findings suggest initial intervention targets for treating depression in autistic early adolescents."],"journal":["Autism : the international journal of research and practice"],"pubmed_title":["Diagnostic- and sex-based differences in depression symptoms in autistic and neurotypical early adolescents."],"pmcid":["PMC8710183"],"funding_grant_id":["U54 HD083211","P50 HD103537","UL1TR000445","UL1 TR000445","R01 MH111599","T32 GM007347","F32 MH011599","R01MH11599"],"pubmed_authors":["Corbett BA","Schwartzman JM","Williams ZJ"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic- and sex-based differences in depression symptoms in autistic and neurotypical early adolescents.","description":"<h4>Lay abstract</h4>Depression is more common in autistic adolescents than their neurotypical peers, but the effects of diagnosis and sex on the severity and types of depressive symptoms remain unclear. The study explored diagnostic- and sex-based differences in depressive symptoms in 212 autistic and neurotypical early adolescents. Results show that autism spectrum disorder and female may pose elevated risks, and depressive symptoms related to interpersonal problems and negative self-esteem are more frequent in autism spectrum disorder. Autistic males and females endorsed similar severity and type of depressive symptoms, but unique differences emerged when compared to sex-matched neurotypical peers. Exploratory analyses in a clinical subsample of early adolescents with elevated depressive symptoms (Children's Depression Inventory, Second Edition, Total <i>T</i>-score ⩾60) revealed more endorsement of beliefs of worthlessness in autistic early adolescents. Findings suggest initial intervention targets for treating depression in autistic early adolescents.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-19T18:09:38.283Z","creation":"2025-04-19T18:09:38.283Z"},"accession":"S-EPMC8710183","cross_references":{"pubmed":["34180264"],"doi":["10.1177/13623613211025895"]}}