{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pang J"],"funding":["NIH CTSA","NCATS NIH HHS","NIDCR NIH HHS","NIDCD NIH HHS","NCI NIH HHS","NINDS NIH HHS","NIH NIDCR","NIGMS NIH HHS","NIH NIDCD"],"pagination":["6772-6786"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8710294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(24)"],"pubmed_abstract":["<h4>Purpose</h4>Human papillomavirus (HPV) plays a major role in oncogenesis and circular extrachromosomal DNA (ecDNA) is found in many cancers. However, the relationship between HPV and circular ecDNA in human cancer is not understood.<h4>Experimental design</h4>Forty-four primary tumor tissue samples were obtained from a cohort of patients with HPV-positive oropharynx squamous cell carcinoma (OPSCC). Twenty-eight additional HPV oropharyngeal cancer (HPVOPC) tumors from The Cancer Genome Atlas (TCGA) project were analyzed as a separate validation cohort. Genomic, transcriptomic, proteomic, computational, and functional analyses of HPVOPC were applied to these datasets.<h4>Results</h4>Our analysis revealed circular, oncogenic DNA in nearly all HPVOPC, with circular human and human-viral hy"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription."],"pmcid":["PMC8710294"],"funding_grant_id":["R01 NS073831","UL1TR001442","R01 CA204264","T32 GM008806","T32 DC000028","UL1 TR001442","R01 DE023347","CA204264-01","R01DE023347-04","U24 CA264379","R01 GM114362"],"pubmed_authors":["Ball L","Bafna V","Fisch K","Sadat S","Nguyen N","Guo T","Xu G","Califano J","Finegersh A","Flagg M","Mischel PS","Luebeck J","Pang J","Panuganti B","Nakagawa T","Cahill G","Ren S"],"additional_accession":[]},"is_claimable":false,"name":"Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription.","description":"<h4>Purpose</h4>Human papillomavirus (HPV) plays a major role in oncogenesis and circular extrachromosomal DNA (ecDNA) is found in many cancers. However, the relationship between HPV and circular ecDNA in human cancer is not understood.<h4>Experimental design</h4>Forty-four primary tumor tissue samples were obtained from a cohort of patients with HPV-positive oropharynx squamous cell carcinoma (OPSCC). Twenty-eight additional HPV oropharyngeal cancer (HPVOPC) tumors from The Cancer Genome Atlas (TCGA) project were analyzed as a separate validation cohort. Genomic, transcriptomic, proteomic, computational, and functional analyses of HPVOPC were applied to these datasets.<h4>Results</h4>Our analysis revealed circular, oncogenic DNA in nearly all HPVOPC, with circular human and human-viral hy","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-09T03:19:39.733Z","creation":"2025-02-19T02:57:03.521Z"},"accession":"S-EPMC8710294","cross_references":{"pubmed":["34548317"],"doi":["10.1158/1078-0432.CCR-21-2484","10.1158/1078-0432.ccr-21-2484"]}}